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作 者:张惠新[1] 姜博仁[1] 李影[1] 李艳香[1] 夏芳珍[1]
机构地区:[1]上海交通大学医学院附属第九人民医院内分泌代谢研究室,上海200011
出 处:《中国医药导报》2011年第28期48-49,共2页China Medical Herald
基 金:国家自然科学基金(项目编号:81000345)
摘 要:目的:探讨年龄32~56岁的健康者体质指数(body mass index,BMI)增高对血压、血糖、糖化血红蛋白及C肽的影响。方法:79名健康者按BMI分为标准组(18.5≤BMI<24,n=44)、超重组(24≤BMI<28,n=27)及肥胖组(BMI≥28,n=8)三组,比较三组之间血压、血糖、糖化血红蛋白及C肽的变化。结果:随着BMI的增高,收缩压(SBP)[(115.8±15.24)mm Hg vs(121.1±18.38)mm Hg vs(133.4±18.36)mm Hg](1 mm Hg=0.133 kPa)、餐后2 h血糖(PBG)[(5.76±0.73)mmol/L vs(5.86±0.76)mmol/L vs(6.61±1.85)mmol/L],及糖化血红蛋白(HbA1C)[(5.20±0.29)%vs(5.29±0.28)%vs(5.64±0.53)%]显著增高,差异有统计学意义(P=0.033,P=0.048,P=0.004);而舒张压(DBP)[(72.57±11.14)mm Hg vs(75.81±10.04)mm Hg vs(80.71±11.31)mm Hg]、空腹血糖(FBG)[(5.73±0.52)mmol/L vs(5.48±0.54)mmol/L vs(5.85±0.61)mmol/L]、空腹C肽[(1.37±0.81)pmol/L vs(1.26±0.43)pmol/L vs(1.98±0.75)pmol/L]及餐后2 h C肽[(2.70±1.14)pmol/Lvs(2.99±1.49)pmol/L vs(3.25±1.53)pmol/L]也有增高趋势,但差异无统计学意义(P=0.137,P=0.107,P=0.110,P=0.530)。结论:肥胖使血压、血糖水平增加,从而增加高血压以及糖尿病的患病风险。Objective: To investigate the influence of body mass index(BMI) increasing on levels of blood pressure,blood glucose,glycosylated hemoglobin and C-peptide in the healthy people aged from 32 to 56.Methods: 79 healthy subjects were divided by BMI to three groups,standard group(18.5≤BMI24,n=44),overweight group(24≤BMI28,n=27) and obese group(BMI≥28,n=8),the levels of blood pressure,blood glucose,glycated hemoglobin and C-peptide among the three groups were compared.Results: With the increasing of BMI,the levels of systolic blood pressure(SBP) [(115.8±15.24)mm Hg vs(121.1±18.38)mm Hg vs(133.4±18.36)mm Hg](1 mm Hg=0.133 kPa),2-hour postprandial blood glucose(PBG) [(5.76±0.73)mmol/L vs(5.86±0.76)mmol/L vs(6.61±1.85)mmol/L] and glycated hemoglobin(HbA1C) [(5.20±0.29)% vs(5.29±0.28)% vs(5.64±0.53)%] were significantly higher with statistically significant(P=0.033,P=0.048,P=0.004);and levels of diastolic blood pressure(DBP) [(72.57±11.14)mm Hg vs(75.81±10.04)mm Hg vs(80.71±11.31)mm Hg],fasting glucose(FBG) [(5.73±0.52)mmol/L vs(5.48±0.54)mmol/L vs(5.85±0.61)mmol/L],fasting C-peptide [(1.37±0.81)pmol/L vs(1.26±0.43)pmol/L vs(1.98±0.75)pmol/L] and postprandial 2 h C peptide [(2.70±1.14)pmol/L vs(2.99±1.49)pmol/L vs(3.25±1.53)pmol/L] also tended to increase,but the difference was not significant(P=0.137,P=0.107,P=0.110,P=0.530).Conclusion: Obesity makes levels of blood pressure,blood glucose increase,thereby increasing the risk to high blood pressure,heart disease,cerebrovascular disease and diabetes.
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