头孢曲松相关假性结石  

Ceftriaxone-associated pseudolithiasis

作　　者：高晨[1] 周颖[2] 

机构地区：[1]首都医科大学附属北京天坛医院药剂科,北京100050 [2]北京大学第一医院药剂科,北京100034

出　　处：《药物不良反应杂志》2011年第4期236-239,共4页Adverse Drug Reactions Journal

摘　　要：头孢曲松是第3代头孢菌素,具有广谱抗菌作用。该药易与胆汁和尿液中的钙离子结合,成为头孢曲松钙盐沉淀物,进而形成假性结石。多数头孢曲松相关假性结石患者无临床症状,超声检查是该病诊断的最常用方法,询问病史及用药情况有助于确诊。用药剂量、疗程、静脉滴注速度及禁食与脱水状态是头孢曲松相关假性结石发生的主要影响因素。假性结石具有可逆性,停药后可自行消失,无需手术。必要时应予对症治疗。Ceftriaxone is a third generation cephalosporin,and it has a broad-spectrum antimicrobial activity.Ceftriaxone readily forms a precipitate of calcium-ceftriaxone salt with calcium in bile and urine,and this results in formation of pseudostone.Most patients with ceftriaxone-associated pseudolithiasis are asymptomatic.Ultrasonography is the most usual method for the diagnosis of ceftriaxone-associated pseudostone.Review of medical history and drug usage is helpful for an accurate diagnosis.The main risk factors for ceftriaxone-associated pseudolithiasis development include dosage,duration of treatment,rate of intravenous infusion,fasting,and dehydration.Ceftriaxone-associated pseudolithiasis is reversible and resolves spontaneously after drug withdrawal,there is no need for any operations.Symptomatic treatment should be given,if necessary.

关 键 词：头孢曲松 假性结石 

分 类 号：R595.3[医药卫生—内科学]