萝芙木致药物性肝炎  

Drug-induced hepatitis due to devilpepper root

作　　者：何洁宝[1] 何敬成[2] 张碧青[3] 陆晓晖[2] 罗蓓[2] 

机构地区：[1]广东省佛山市顺德第一人民医院神经内科,广东佛山528300 [2]广东省佛山市顺德第一人民医院药剂科,广东佛山528300 [3]广东省佛山市顺德第一人民医院神经外科,广东佛山528300

出　　处：《药物不良反应杂志》2011年第4期262-263,共2页Adverse Drug Reactions Journal

摘　　要：1例45岁男性患者因咽痛自行服用萝芙木煎剂(250 ml相当25 g),3次/d。服药第4天出现尿黄,第7天出现恶心、呕吐、乏力、纳差、皮肤和巩膜黄染,第9天入院。实验室检查:丙氨酸转氨酶(ALT)1 735 U/L,天冬氨酸转氨酶(AST)682 U/L。诊断为药物性肝炎。立即停用萝芙木,给予茵栀黄口服颗粒剂和谷胱甘肽、苦参碱、甘草酸二铵静脉滴注治疗。入院第12天复查肝功能:ALT97 U/L,AST 32 U/L,患者痊愈出院。A 45-year-old male patient himself took devilpepper root decoction（250 ml equivalent to 25 g） thrice daily for sore throat.On day 4 of treatment start,he developed yellowish urine,On day 7,he developed nausea,vomiting,asthenia,anorexia, yellowish skin and sclera.On day 9,he was hospitalized.Laboratory tests showed the following values;ALT 1735 U/L,AST 682 U/L. He was diagnosed with drug-induced hepatitis.Devilpepper root was discontinued immediately and he was given oral Yinzhihuang granule,followed by infusions of glutathione,matrine and diammonium glycyrrhizinate.On hospital day 12,repeat liver function tests revealed the following levels：ALT 97 U/L,AST 32 U/L.He recovered well and was discharged.

关 键 词：萝芙木 药物性肝炎 

分 类 号：R595.3[医药卫生—内科学]