超微七味白术散对菌群失调小鼠的疗效研究  

Effects of Ultra-micro Powder of Qiweibaizhu on Dysbacteriosis in Mice with Diarrhea

作　　者：邓红洁[1] 吴海[2] 彭晓珊[1] 蔡光先[2] 张熙[2] 谭周进[2] 欧阳锋[1] 

机构地区：[1]湖南中医药大学湘杏学院,湖南长沙410208 [2]湖南中医药大学,2009级研究生湖南长沙410208

出　　处：《现代生物医学进展》2011年第19期3632-3635,共4页Progress in Modern Biomedicine

基　　金：2010年湖南省大学生研究性学习和创新性实验计划项目(湘教通[2010]244号);湖南省科技厅重点项目(2010SK2002)

摘　　要：目的:研究超微七味白术散对抗生素引起的菌群失调小鼠的疗效。方法:将70只小鼠随机分为7组,以灌胃生理盐水建立对照组,以灌胃氨苄西林、头孢拉定、盐酸林可霉素复合抗生素构建菌群失调小鼠模型,以七味白术散传统汤剂及超微全量、1/2量、1/4量、1/8量治疗,通过粪便判断疗效。结果:七味白术散超微药剂与传统汤剂均能治疗抗生素引起的小鼠菌群失调,且超微七味白术散1/2量对小鼠的治疗效果已能达到传统汤剂水平。结论:超微七味白术散对菌群失调小鼠具有良好的治疗效果,与传统药物相比具有节约药材的价值。Objective： To investigate the effect of ultra-micro powder of Qiweibaizhu on the diarrhea with dysbacteriosis induced by antibiotics in mice. Methods： 70 mice were randomly divided into 7 groups： the control group, the model group, the Qiweibaizhu decoction of traditional drugs group, the whole amount of superfine powder group, the 1/2 volume, the 1/4 volume and the 1/8 volume group. Except for the mouse in control group, all the mouse were fed with complex antibiotic made up of ampicillin, cephradine, lincomycin to simulate the diarrhea with dysbacteriosis models. And then, all tlte mouse were injected with drugs into the stomach 3 days. In the whole process, the mouse in control group were given saline. After that, the treatment effect was determined by the feces. Results： The dysbacteriosis of mice can be cured by both ultra-micro powder and decoction of traditional drugs of Qiweibaizhu, and the therapeutic effect in mice of 1/2 the amount of ultra-micro powder of Qiweibaizhu has been able to reach the level of the traditional decoction. Conclusion： The ultra-micro powder of Qiweibaizhu has a good therapeutic effect on dysbacteriosis in mice, and can save medicinal material compared to traditional medicines.

关 键 词：菌群失调 超微饮片 七味白术散 

分 类 号：Q95-3[生物学—动物学] R285.5[医药卫生—中药学]