MicroRNA在肿瘤诊断、治疗中的应用  

Application of MicroRNA in Cancer Diagnosis and Therapy

作　　者：魏清筠[1,2] 朱远源[1,2] 彭薇 王旻[1] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]百奥迈科生物技术有限公司,江苏南通226016

出　　处：《现代生物医学进展》2011年第19期3794-3797,共4页Progress in Modern Biomedicine

摘　　要：MicroRNA(miRNA)是真核生物中一类内源性、长约22个核苷酸的非编码小分子RNA,参与基因转录后水平调控。miRNA的突变或者异常表达,与大多数癌症的发生发展有关,且与某些抗肿瘤药物疗效密切相关。因此,miRNA在癌症的诊断、预后、治疗和指导肿瘤个体化用药方面具有一定的临床应用潜力,是肿瘤生物治疗领域的一个新亮点。本文即对miRNA在诊断和治疗肿瘤方面的应用现状作一综述。MicroRNA（miRNA） is a class of cndogenous, small, noncoding RNAs, about 22 nuclcotides in length, functioning as posttranscriptional gene regulators, miRNA mutation and abnormal expression were found to correlate with the initiation and progression of human cancers and therapeutic effects of some antltumor drugs as well. Hence, mIRNA shows potential applications in cancer dlagnosis, staging, prognosis and treatment, which make it a highlight in the field of tumor biological therapy. This review provides an overview of the application of miRNA in cancer diagnosis and therapy.

关 键 词：MICRORNA 肿瘤 诊断 治疗 

分 类 号：Q730.54[生物学—分子生物学]