双水平正压通气对急性左心衰患者脑利钠肽前体浓度的影响  

Survey effect on NT-proBNP in acute left heart failure patient with bi-level positive airway pressure ventilator

作　　者：朱可云[1] 陶卫国[1] 梁转合[1] 

机构地区：[1]南方医科大学附属新会医院,529100

出　　处：《中国医学创新》2011年第29期6-8,共3页Medical Innovation of China

摘　　要：目的观察双水平正压通气(BiPAP)对急性左心衰患者脑利钠肽前体(NT-proBNP)的影响。方法入选64例急性左心衰患者,32例采用常规抗心衰治疗,另外32例在常规抗心衰治疗基础上加用BiPAP治疗。两组患者分别在入院时、12 h、24 h抽血检测NT-proBNP,行动脉血气分析,同时监测呼吸频率(RR)、心率(HR)、平均动脉压(MAP)。结果 (1)NT-proBNP随着治疗进行显示逐渐降低趋势,BiPAP组下降得更低,在24 h后两组比较差异有统计学意义(P<0.05)。(2)所有患者临床症状改善,两组PaO_2、HR、MBP差异均有统计学意义(P<0.05),治疗组优于对照组。结论 BiPAP治疗较常规治疗使急性左心衰患者NT-proBNP浓度降低更显著,表明BiPAP组对急性左心衰的疗效更好。Objective To survey the effect of bi - level positive airway pressure ventilator（BiPAP） on N - terminal pro - brain natriuretic peptide（ NT - proBNP） in acute left heart failure patient. Methods 64 patients of acute left heart failure were recruited to the study group, 32 patients in treatment group were applied by BiPAP treatment,another 32 patients in control treatment group were treated by usual oxygen treatment. All patients were detected artery gas,NT -proBNP at the time of 12 hours and 24 hours, meanwhile, as well as respiratory rate（RR） , heart rate（HR） , and mean artery pressure（MAP）. Results （ 1 ） Clinic symptoms of all patients were improved, but HR and MAP were significantly different after 24 hours treatment （P 〈 0.05 ）, quantitative value of treatment group was lower than control one＇s. （ 2 ） The level of NT - proBNP was gradually lower with treatment in all patients, it was significantly different between the two groups after 24 hours treatment （P 〈0.05）. （3） Arterial partial pressure of oxygen （ PaO2 ） significantly increased after 12 hours treatment （ P 〈 0.05 ） , treatment level was higher than control one＇s. Conclusion NT - proBNP level of acute left heart failure is rapid reduced by BiPAP, hemodynamics is early improved with BiPAP.

关 键 词：BIPAP 急性左心衰 NT—proBNP 

分 类 号：R541.6[医药卫生—心血管疾病]