炎琥宁与利巴韦林治疗儿童手足口病疗效的Meta分析  

A Meta-analysis on Effectiveness of Yanhuning versus Ribavirin in the Treatment of Children with Hand-foot-and-mouth Disease

作　　者：陈富超[1] 陈茜[1] 方宝霞[1] 朱军[1] 

机构地区：[1]湖北医药学院附属东风医院,湖北十堰442008

出　　处：《儿科药学杂志》2011年第5期13-16,共4页Journal of Pediatric Pharmacy

摘　　要：目的:评价炎琥宁与利巴韦林治疗儿童手足口病的疗效。方法:计算机检索万方医学网与中文科技期刊全文数据库(VIP),纳入炎琥宁与利巴韦林治疗儿童手足口病的随机对照试验文献(RCT),并进行方法学质量评价和采用RevMan 5.0软件进行Meta分析。结果:纳入12篇RCT,共1 446例患者符合纳入标准。Meta分析结果显示:炎琥宁组与利巴韦林组的痊愈率和有效率比较差异有统计学意义,RR(95%CI)分别为2.35(1.86,2.96)与4.66(3.01,7.21);且退热时间与疱疹消退时间比较差异也有统计学意义,MD(95%CI)分别为-1.41(-1.84,-0.98)和-1.60(-2.11,-1.10)。结论:基于当前证据,炎琥宁治疗儿童手足口病疗效优于利巴韦林,但受纳入文献质量影响,以上结论需要高质量的临床证据进一步证实。Objective：To evaluate the efficacy of Yanhuning and ribavirin in the treatment of children with Hand-foot-and-mouth disease.Methods： The randomized controlled trials of Yanhuning and ribavirin for Hand-foot-and-mouth disease in children were gathered from VIP and Wanfang data bases.The methodological qualities of included studies were evaluated,and data analysis was performed with Cochrane Collaboration＇s software RevMan 5.0.Results： A total of 1,446 patients involved in 12 trails were searched.As for the clinical cure rates and clinical effective rates in the treatment of children with Hand-foot-and-mouth disease,significant differences were noted between Yanhuning and ribavirin;RR（95%CI） were 2.35（1.86 to 2.96）,4.66（3.01 to 7.21） respectively.The fever clearance time and rash subsided time were statistically different between Yanhuning and ribavirin;MD（95%CI） were-1.41（-1.84 to 0.98）,-1.60（-2.11 to-1.10） respectively.Conclusions： According to the current evidence,Yanhuning is effective in the treatment of children with Hand-foot-and-mouth disease versus ribavirin.However,more high quality clinical trials are expected for further study.

关 键 词：炎琥宁 利巴韦林 儿童 手足口病 META分析 

分 类 号：R725.7[医药卫生—儿科]