双氯芬酸对盐酸莫西沙星在大鼠体内的药动学影响  

Effects of Diclofenac on Moxifloxacin Pharmacokinetics in Rats

作　　者：董洁[1] 陈晓乐[1] 林高通[1] 阚歆[2] 张潇云[1] 张秀华[3] 

机构地区：[1]温州医学院,浙江温州325035 [2]温州市第三人民医院,浙江温州325000 [3]温州医学院附属第一医院,浙江温州325000

出　　处：《中国药学杂志》2011年第19期1509-1512,共4页Chinese Pharmaceutical Journal

摘　　要：目的研究双氯芬酸对莫西沙星在大鼠体内药动学的影响。方法采用平行对照实验设计,健康雄性SD大鼠18只随机分成2组,单用莫西沙星组(ig 40 mg.kg-1)和双氯芬酸与莫西沙星联合使用组(ig 25 mg.kg-1双氯芬酸,ig 40 mg.kg-1莫西沙星)。采用HPLC测定莫西沙星的血药浓度。用DAS2.0程序计算主要药动学参数,并进行统计分析。结果健康雄性SD大鼠灌胃给药:单用组、联用组莫西沙星ρmax分别为(6.7±1.1)和(4.4±1.0)mg.L-1,tmax分别为(0.9±0.2)和(1.2±0.2)h;AUC0-t分别为(34.4±9.6)和(27.5±7.8)mg.h.L-1,AUC0-∞分别为(41.2±12.2)和(30.8±11.9)mg.h.L-1;t1/2分别为(9.0±5.7)和(6.2±3.7)h;Clz/F分别为(1.1±0.5)和(1.4±0.5)mL.h-1.g-1,联用组莫西沙星的AUC0-t、AUC0-∞和ρmax均显著小于单用组(高侧P>0.05,低侧P<0.05),两组莫西沙星tmax、t1/2和Clz/F比较无统计学意义(P>0.05)。结论双氯芬酸和莫西沙星联合用于大鼠时,双氯芬酸使莫西沙星的AUC和ρmax减小,临床上应注意两药联用时的给药剂量的调整。OBJECTIVE To develop a high performance liquid chromatography method for the determination of moxifloxacin in rat plasma.To study the effects of diclnfenac on moxifloxacin pharmacokinetics in rats. METHODS Using parallel control design , 18 Sprague-Dawley Rats were randomly divided into 2 groups （n = 9 each ） ： group M, moxifloxacin without diclofenac and group DM, mnxifloxacin with Diclofenac. In grouop M, rats were given 40 mg · kg^-1 moxifloxacin orally ; In grouop DM, rats were given 25 mg·kg^-1 Diclofenac and 40 mg·kg^-1 moxifloxacin orally. The concentrations of moxifloxacin in plasma were determined by HLPC. The pharmacokinetic parameters were calculated by DAS2. 0 programme. RESULTS The obtained pharmacokinetiC parameters of moxifloxacin in plasma were as follows： Pmax in group M （6. 7 ± 1. 1 ）mg·kg^-1 was significantly higher than that in group DM （4. 4 ± 1.0）mg·kg^-1, accompanied by significant increase of AUC0-t （34. 4 ± 9. 6） mg·h·L^- 1 vs （27. 5 ± 7. 8） mg · h · L^-1 and AUC0-∞（41.2± 12. 2） mg· h · L^-1 vs （30. 8 ± 11.9） mg·h· L^-1 （high side P 〉0. 05 ,low side P 〈0. 05）. No differences between two groups in t t1/2 and Cl2/F were found （P 〉 0. 05 ）. CONCLUSION When Dielofenae and moxifloxacin are simultaneously used in rats, Diclofenal decreases AUC and ρmax of moxifloxacin. When both drags are used in clinical application, the dosage should be restricted.

关 键 词：莫西沙星 双氯芬酸 药动学 高效液相色谱法 

分 类 号：R969.1[医药卫生—药理学]