真菌对临床抗真菌药物的耐药机制  

Mechanisms of antifungal drug resistance

作　　者：崔宇慧[1] 唐建国[1] 

机构地区：[1]复旦大学附属上海市第五人民医院重症医学科,上海200240

出　　处：《中国抗生素杂志》2011年第10期733-737,共5页Chinese Journal of Antibiotics

摘　　要：真菌感染,尤其是深部真菌感染的发病率近年来呈上升趋势,抗真菌药物的大量使用引起了真菌耐药日益严重,严重影响了抗真菌药物治疗的效果,也增加了危重患者的病死率,因此对真菌耐药机制的研究十分必要。本文依据常用抗真菌药物的药物种类,分别总结论述了近年来真菌耐药机制研究的新进展。In recent years, the morbidity of fungal infections especially invasive fungal infections increase continuously, as a result, plenty use of antifungal agents induce the worse condition of antifungal drug resistance, the effect of antifungal drug therapy is badly damaged, and the mortality of the severe patients is also increased. So it is necessary to discuss the mechanisms of drug resistance. In this review, the new progresses of researches in antifungal drug resistance will be related according to the drug classes respectively.

关 键 词：真菌 耐药机制 抗真菌药物 

分 类 号：R379[医药卫生—病原生物学]