抗磷脂冲剂对小鼠抗心磷脂抗体的影响  

Antiphospholipid Granule's Impact on Anti-Cardiolipin Antibodies in Mice

作　　者：孟安琪[1] 鲁立宪[1] 赵聪聪[1] 李明明[1] 张莹[1] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2011年第10期2095-2096,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省教育厅资助项目(2008440)

摘　　要：目的:观察抗磷脂冲剂对环磷酰胺所致的抗心磷脂抗体产生的影响。方法:通过建立环磷酰胺所致小鼠体内产生ACA的模型,观察中药抗磷脂冲剂对ACA的影响。结果:环磷酰胺能导致小鼠体内产生ACA,抗磷脂冲剂对环磷酰胺所致的小鼠体内ACA有明显的降低作用,并随着使用剂量的增加,小鼠体内的ACA降低效果更明显。结论:抗磷脂冲剂能够有效的降低小鼠体内的ACA水平,并抑制抗磷脂抗体的产生及其对胚胎的损害,从而达到保胎的目的。Objective：To observe the impact of antiphospholipid granule on anti-cardiolipin antibodies induced by cyclophosphamide.Methods：With the establishment of cyclophosphamide-induced mice model in vivo ACA,to observe the effects of Antiphospholipid granules of traditional Chinese medicine on ACA.Results：Cyclophosphamide can lead to ACA production,Antiphospholipid granule has a significant role in reducing ACA,and as the dose increaing,ACA reducing effects of mice is more obvious.Conclusion：Antiphospholipid granules can effectively reduce the ACA levels in mice and inhibie Antiphospholipid antibodies and its damage to the embryo so as to achieve the objective of Preventing miscarriage

关 键 词：免疫性流产 抗磷脂冲剂 抗心磷脂抗体 

分 类 号：R714.21[医药卫生—妇产科学]