注射用氨溴索雾化吸入致呼吸困难1例分析  

Reason Analysis of 1 Case of Dyspnea Induced by Aerosol Inhalation of Ambroxol

作　　者：王明丽[1] 谢陶吟[1] 许建平[1] 

机构地区：[1]江苏常州市第一人民医院,常州市213003

出　　处：《中国药房》2011年第40期3791-3792,共2页China Pharmacy

摘　　要：目的:提示临床重视雾化吸入注射用氨溴索所致不良反应。方法:报道我院注射用氨溴索雾化使用致不良反应1例,并检索中国期刊全文数据库(CNKI)中注射用氨溴索致不良反应的相关文献,进行分析。结果:文献检索仅得到1例雾化吸入注射用氨溴索致过敏反应的报道,而我院近年注射用氨溴索雾化使用除1例致呼吸困难外,未见其他严重不良反应。氨溴索本身并不会引起呼吸困难,之所以出现不良反应可能与雾化因素和药物pH值有关。结论:注射用氨溴索的雾化使用需要谨慎,其长期安全性尚有待进一步考察。OBJECTIVE： To explore the causes of adverse drug reaction of aerosol inhalation of ambroxol and make suggestions for safe drug use in the clinic. METHODS： The use of aerosol inhalation of ambroxol in our hospital was investigated. Relevant literatures of adverse drug reaction （ADR） of ambroxol were retrieved from CNKI and analyzed systematically. RESULTS： Only one allergy case was found in literature and no serious ADR was caused by aerosol inhalation of ambroxol in our hospital recently. Thus, there was little relationship between dyspnea and ambroxol itself Aerosol inhalation and pH value of ambroxol injection were more important factors of ADR. CONCLUSION： The use of aerosol inhalation of ambroxol should be paid more attention. And there is further work needed to investigate its long-term safety.

关 键 词：氨溴索 注射剂 雾化吸入 呼吸困难 分析 

分 类 号：R969.3[医药卫生—药理学]