根皮素异烟酰基腙的合成、表征及抗氧化活性研究  

Synthesis,Characterization,and Antioxidant Activity of Phloretin Isonicotinyl Hydrazone

作　　者：李静[1] 余燕影[2] 曹树稳[1,2] 

机构地区：[1]食品科学与技术国家重点实验室南昌大学,南昌330047 [2]南昌大学化学系,南昌330031

出　　处：《天然产物研究与开发》2011年第5期824-827,共4页Natural Product Research and Development

基　　金：国家自然科学基金项目(20962014)

摘　　要：本文旨在提高根皮素的生物活性,以其作为母体通过与异烟肼结合引入C=NNH活性基团,合成了一种新型酰腙类化合物。采用UV,IR,1H NMR,13C NMR及元素分析等手段对产物进行结构表征,并测定了根皮素及其异烟酰基腙的还原能力,清除DPPH自由基及清除ABTS自由基能力。结果表明根皮素异烟酰基腙的抗氧化活性显著优于根皮素。To improve the biological activity of ptdoretin, a novel hydrazone was synthesis with phloretin and isoniazid, and the target compound was characterized by UV, IR, 1 H NMR, 13 C NMR and elemental analysis, respectively. Reducing power, DPPH and ABTS · radical scavenging assays were carried out to evaluate the antioxidant and free radical scav- enging abilities of phloretin and its hydrazone. The results showed that the antioxidant and free radical scavenging abilities of hydrazone was stronger than phloretin.

关 键 词：腙 根皮素 异烟肼 合成 抗氧化 

分 类 号：R284.3[医药卫生—中药学]