延衰合剂对D-半乳糖衰老模型小鼠学习记忆及抗氧化能力的影响(英文)  

Effects of Yanshuai Mixture on the Learning Memory and Antioxidative Capacity in D-galactose Induced Aging Mice

作　　者：栾增强[1] 曹文富[1] 彭爽[1] 黄和贤[1] 

机构地区：[1]重庆医科大学附属第一医院中西医结合科,重庆400016

出　　处：《天然产物研究与开发》2011年第5期837-841,共5页Natural Product Research and Development

摘　　要：为观察延衰合剂(Yanshuai mixture,YSM)的延缓衰老作用,采用D-半乳糖连续颈背部皮下注射诱导亚急性衰老小鼠模型,造模同时给予YSM低、中、高剂量灌胃,连续10周。观察小鼠衰老征象,Moriss水迷宫检测学习记忆功能,测定血清及脑组织中总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)。结果显示,与模型组比较,YSM各剂量组均能使小鼠逃避潜伏期明显缩短,原平台象限游泳时间明显延长(P<0.05);YSM高剂量组T-AOC、SOD活性显著升高(P<0.01),MDA水平显著下降(P<0.01)。表明YSM可明显改善衰老小鼠学习记忆功能,提高抗氧化能力,从而可能具有较好的延缓衰老的作用。This study was conducted to investigate the anti-aging effect of Yanshuai mixture （YSM）. The subacute aging model mice were induced by D-galactose injected subcutaneously. At the same time,low,medium and high dose of YSM were administered intragastricaUy once daily for 10 weeks. Signs of aging were observed. The Moriss Water Maze test was used to evaluate the learning and memory function. The levels of T-AOC, T-SOD, and MDA in the serum and brain tissue were measured. Results show that YSM shortened the escape latency of the aging model mice,while prolonged the original platform quadrant swimming time significantly compared with the model group （P 〈 0.05）. High dose of YSM increased the T-AOC, SOD activites of the aging model mice, and decreased the MDA content Significantly （P 〈 0.01 ）. It is indicated that YSM can improve the learning and memory ability and increase antioxidative capacity of aging mice, which may has a good anti-aging effect.

关 键 词：延衰合剂 衰老 学习记忆 T-AOC SOD MDA 

分 类 号：R285.5[医药卫生—中药学]