不同麻醉方式对腹腔镜子宫次切术围术期GRO-1、IP-10的影响  

Effect of Anesthesia Mode on Plasm Chemokines GRO-1 and IP-10 of Sufferer Surround Laparoscopic Hysterectomy

作　　者：史思仁[1] 骆秀琴[1] 郑恭[1] 陈永花[1] 赵毅敏[1] 倪建华[1] 胡燕[1] 

机构地区：[1]杭州师范学院医学院附属余杭医院麻醉科,311100

出　　处：《医学研究杂志》2011年第9期91-94,共4页Journal of Medical Research

基　　金：杭州市余杭区科技局资助项目(2007-103)

摘　　要：目的观察不同麻醉方式围术期对血浆趋化因子GRO-1、IP-10的变化,研究不同麻醉方式围术期对腹腔镜下子宫次切术患者免疫功能和肿瘤转移的影响。方法选择ASAⅠ～Ⅱ级腹腔镜下子宫次切术患者60例,随机分为3组:全凭静脉麻醉组(A组),静吸复合麻醉组(B组),全麻联合硬膜外阻滞组(C组),每组各20例。在麻醉前(T0)、术毕(T1)、术后24h(T2)、术后48h(T3)和出院前2h(T4)观察各时点MAP、HR、RR、SpO2,采集外周静脉血测定趋化因子GRO-1、IP-10浓度。结果患者血浆GRO-1、IP-10浓度术后均有不同程度的降低,其中B组T1时较A、C组降低更加明显;3组各时点间差异均无显著性意义。结论不同麻醉方式对围术期腹腔镜下子宫次切术患者免疫功能和肿瘤转移的影响无显著性差异,均可安全应用于腹腔镜下子宫次切术患者的麻醉。Objective To select different anesthesia mode during perioperative laparoscopic hysterectomy and to assess the concen- tration of GRO - 1 and IP - 10 in plasma and to investigate the influence on the paitents＇ immune function and tumor metastasis. Methods The sixty paitents belonging to ASAⅠ-Ⅱ who will accept the laparoscopic hysterectomy were averagely divided into 3 groups at random ： total intravenous anesthesia（ A group） ,intravenous combined with inhalation anesthesia（ B group） ,general anesthesia combined with epi- dural block （ C group）. There were four observation points ： before anesthesia（ T0 ）, after operation（ T1 ）, twenty four hours after operation （T2 ）, forty eight hours after operation （T3 ）, two hours before discharge （T4 ）. At each point, we would observe the change of the MAP, H R, RR,SpO2 and collect the perpheral blood for measuring the concentration of Chemokines GRO - 1 and IP - 10 in plasma. Results The concentration of GRO - 1 and IP - 10 in plasma was decreased after operation,while the results at T1 point in B group were significantly lower than those of A and C group. The difference of each point among groups had no statistical significance. Conclusion The different anesthesia mode during perioperative laparoscopic hysterectomy has no statistical significance to the paitents＇ immune function and tumor metastasis, so they can be safely used.

关 键 词：麻醉 趋化因子 腹腔镜子宫次切术 生长相关性癌基因-1 干扰素诱生蛋白-10 

分 类 号：R713.42[医药卫生—妇产科学]