HIV/AIDS合并早期隐性梅毒患者淋巴细胞HLA-DR抗原表达  

Expression of HLA-DR Antigen of Lymphocyte in Patients with Earlylatent-syphilis and Human Immunodeficiency Virus Co-infection

作　　者：章松平[1] 朱明利[1] 厉小玉[1] 周俊[1] 潘熠健[1] 李超丹[1] 

机构地区：[1]杭州市第六人民医院开放实验室,310014

出　　处：《医学研究杂志》2011年第9期116-118,共3页Journal of Medical Research

摘　　要：目的研究HIV/AIDS合并早期隐性梅毒患者外周血淋巴细胞HLA-DR抗原的表达,探讨其临床意义。方法用流式细胞仪检测72例HIV患者、45例HIV/AIDS合并早期隐性梅毒患者和35例健康体检者外周血T淋巴细胞HLA-DR抗原百分比(CD3+HLA-DR+)和B淋巴细胞HLA-DR抗原百分比(CD3-HLA-DR+)。结果与对照组[(6.16±2.47)%]比较,HIV感染合并组和AIDS合并组CD3+HLA-DR+抗原百分比[分别为(16.7±5.13)%和(16.9±5.87)%]显著升高(P均<0.01),HIV感染合并组与AIDS合并组CD3+HLA-DR+抗原百分比差异无统计学意义(P>0.05)。HIV感染合并组CD3-HLA-DR+抗原百分比[(6.79±2.54)%]显著低于AIDS合并组[(12.2±2.47)%,P<0.01]和对照组[(14.7±3.23)%,P<0.01],AIDS合并组CD3-HLA-DR+抗原百分比与对照组差异无统计学意义(P>0.05)。HIV感染合并组CD3-HLA-DR+抗原百分比显著低于HIV感染组(P<0.01),HIV感染合并组与HIV感染组CD3+HLA-DR+抗原百分比无显著性差异(P>0.05),AIDS合并组与AIDS组两组间CD3-HLA-DR+抗原百分比和CD3+HLA-DR+抗原百分比均无显著性差异(P>0.05)。结论 HIV/AIDS合并早期隐性梅毒感染患者外周血T、B淋巴细胞HLA-DR抗原百分比与HIV/AIDS患者存在一定的区别,与HIV进程无明显的相关性。Objective To study the expression of HLA - DR antigen of lymphocyte in patients with eariylatentsyphilis and human immunodeficiency virus coinfection,and investigate the clinical significance. Methods The percentages of CD3 ＋HLA - DR ＋ and CD3 - HLA - DR of lymphocyte were detected by flow cytometry for 72 HIV/AIDS patients,45 patients with earlylatentsyphilis and human immu- nodeficiency virus co - infection and 35 healthy cases. Results Compared with the normal group,the percentages of CD3 ＋ HLA - DR ＋ antigen were significantly increased in co -infection with TP,while there was no difference in the percentage of CD3 ＋ HLA -DR ＋ antigen between HIV and AIDS co - infection with TP. The percentage of CD3 - HLA - DR ＋ antigen in HIV co - infection with TP was significantly decreased in AIDS co - infection with TP and normal group,and there was no difference in the percentage of CD3 - HLA - DR ＋ antigen in AIDS co - infection with TP and normal group. The percentages of CD3 - HLA - DR ＋ antigen in HIV co - infection with TP was significant- ly decreased in those only infected with HIV ,and there was no difference in the percentages of CD3 ＋ HLA -DR ＋ antigen between co -in- fection with TP and only infected with HIV. There was no difference in the percentage of CD3 ＋ HLA - DR ＋ and CD3 - HLA - DR ＋ antigen between AIDS co - infection with TP and AIDS patients. Conclusion The percentages of CD3 ＋ HLA - DR ＋ and CD3 - HLA - DR ＋ anti- gen in co - infection with TP were different with those only infected with HIV,and there was little correlation with HIV progress.

关 键 词：人类免疫缺陷病毒 梅毒螺旋体 HLA—DR抗原 

分 类 号：R512.91[医药卫生—内科学]