分泌粒蛋白Ⅲ的生物学功能与临床意义  

Biological functions and clinical significance of secretogranin Ⅲ

作　　者：李冯锐[1,2] 田晓菲[1] 周懿舒[1] 朱兰卉[1] 庞灏[1] 

机构地区：[1]中国医科大学法医学院,辽宁沈阳110001 [2]包头医学院法医学系,内蒙古包头014060

出　　处：《中国病理生理杂志》2011年第9期1839-1843,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30771833)

摘　　要：分泌粒蛋白Ⅲ（secretogranin III,SCG3/Sg III）是粒蛋白家族（granin family）中一个较新的成员。该蛋白与粒蛋白家族其它成员一样,在分泌颗粒（se-cretory granules）的基质中表达丰富,为亲水性酸性蛋白质,带有丰富的电荷.AIM： Secretogranin Ⅲ（SCG3/Sg Ⅲ） is extensively distributed in endocrine or endocrine-like cells in human body and plays an important role in some biological functions by regulating peptide hormone secretion and neuroendocrine activity.The distribution and functions of SCG3 make itself as not only one of the most useful biological markers in association with neuroendocrine functions,but also a potential indicator of diagnostic and prognostic evaluation in certain diseases.The gene and protein structures,tissue expression,biological functions as well as pathophysiology and clinical significance of SCG3 are reviewed in this article.

关 键 词：分泌粒蛋白Ⅲ 生物学功能 

分 类 号：R3[医药卫生—基础医学]