可溶性CD83对树突状细胞体外诱导T细胞增殖的影响  

Impact of soluble CD83 on dentritic cells induced T lymphocyte proliferation in vitro

作　　者：张衍国[1] 王小霞[1] 李坤[1] 王欢[1] 徐皓[1] 

机构地区：[1]第四军医大学唐都医院皮肤科,西安710038

出　　处：《中国麻风皮肤病杂志》2011年第9期617-619,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:评价可溶性CD83(soluble CD83,sCD83)对树突状细胞(DC)体外诱导的T细胞增殖的影响。方法:采用MTT法检测DC细胞体外诱导的T细胞增殖。结果:与对照组相比,sCD83明显抑制银屑病患者DC细胞体外诱导的T细胞增殖,且与浓度呈正相关。结论:sCD83可望成为治疗银屑病的免疫抑制生物制剂。Objective： To evaluate the impact of sCD83 on dentritic cells （DCs） induced T lymphocyte proliferation in vitro. Methods： T lymphocyte proliferation induced by dentritic cells in vitro was measured by MTT method. Results： Compared with control group, T lymphocyte proliferation induced by dentritlc cells in psoriasis patients was significantly inhibited when cultured with sCD83. Conclusions： sDC83 is possibly a potential agent in the treatment of psoriasis.

关 键 词：可溶性CD83 免疫抑制 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]