原发性肝癌与乙型肝炎肝硬化HBV DNA水平、HBV基因型的比较研究  

Difference of HBV DNA levels and HBV genotypes between the patients with primary hepatocellular carcinoma and liver cirrhosis with hepatitis B

作　　者：王娟华[1] 周敏[1] 李莹[1] 邓俊[1] 吴晓霞[1] 陈卫[1] 顾锡炳[1] 

机构地区：[1]无锡市传染病医院,214005

出　　处：《中华实验和临床病毒学杂志》2011年第4期245-247,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的 比较原发性肝癌与乙型肝炎肝硬化患者的血清HBV DNA水平、HBV基因型差别。方法 对210例原发性肝癌（HCC）患者及220例乙型肝炎肝硬化（HBV LC）患者的血清HBVDNA水平及HBV基因型进行分析，比较病毒学和基因型差异。结果 210例HCC患者和220例HBV LC患者HBV DNA检测阳性率分别为84.3％（177/210）、94.5％（ 208/220）；HBV DNA定量为（5.06±1.01） log10拷贝/ml和（5.36±1.13）log10拷贝/ml，HBV LC患者均高于HCC患者（P＜0.01）；HCC组和HBV LC组均以C基因型为主，两组B，C基因型分布无明显差异。结论 HCC患者血清HBV DNA水平低于HBV LC患者。两组HBV基因型分布无明显差异，均以C基因型为多。Objective To compare the difference of HBV DNA levels and HBV genotypes between the patients with primary hepatocellular carcinoma（HCC） and liver cirrhosis who infected with hepatitis B virus. Methods Total 430 patients with hepatitis B were enrolled and further divided into the HCC group （210 cases） and liver cirrhosis group（ HBV LC, 220 cases）. The levels of HBV DNA and HBV genotypes were detected in all of the serum samples from the two groups, and the differences in the genotypes and virological markers between HCC patients and HBV LC patients were further analyzed. ResultsThe positive rates of HBV DNA of HCC patients and HBV LC patients were 84.3% （177/210） and 94. 5%（208/220） ,respectively. The mean values of serum HBV DNA in HCC patients and HBV-LC patients were （5.06 ± 1. 01 ） log10 cps/ml and （5.36 ± 1. 13）logl0 cps/ml, respectively. The positive rates of HBV DNA and the mean values of serum HBV DNA were higher in HBV-LC patients than those in HCC patients（P 〈0. 01 ）. Furthermore, the main genotype was C in both groups and the distribution of genotype C and genotype B had no statistical difference. Conclusions Mainly presented as a C genotype in both groups, the total levels of serum HBV DNA in HCC patients were lower than those in HBV-LC patients.

关 键 词：肝炎病毒 乙型 肝肿瘤 肝硬化 DNA 基因型 

分 类 号：R512.62[医药卫生—内科学]