跨膜蛋白GARP:一个新的调节性T细胞标志物?  

Transmembrane protein GARP:a novel marker of regulatory T cells?

作　　者：钟禹成[1] 曾秋棠[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心内科,武汉430022

出　　处：《免疫学杂志》2011年第10期899-901,909,共4页Immunological Journal

基　　金：国家自然科学基金项目资助(81070237)

摘　　要：天然产生的CD4+CD25+Treg细胞(nTregs)在维持免疫耐受中的重要作用已得到充分肯定。Forkhead家族转录因子FOXP3被认为对nTreg细胞的发育和功能起关键作用,且为nTreg细胞的一个较特异性的标志物。然而,由于活化的效应性T细胞(Tresp)也上调FOXP3表达。因此,FOXP3仍不能作为nTreg细胞的真正特异性标志物。GARP,一个富含亮氨酸的重复系列的孤独Toll样受体,选择性表达于活化的人类nTreg细胞和nTreg细胞克隆体,但不表达于效应性T细胞,被认为是真正的人类活化的nTreg细胞特异性标志物。另外,GARP能直接结合潜伏相关肽(LAP),诱导潜在的TGF-β转化成活化的TGF-β,从而在nTreg介导的抑制功能中起着一定作用。It has been fully affirmed that naturally occurring CD4＋CD25＋ regulatory T cells（nTregs） are essential for maintaining immune tolerance.Forkhead family transcription factor FOXP3 is required for the development and function of nTreg cells and one of the specific markers for nTreg cells.Many activated effector T cells（Tresp） also express FOXP3,limiting its use as a bona fide marker for nTreg cells.GARP,an orphan toll-like receptor composed of leucine-rich repeats,selectively expressed on the activated human nTreg cells and nTreg cell clones,but not expressed on the effector T cells.Thus,GARP is considered as a bona fide marker for nTreg cells.In addition,GARP,which binds directly to the TGF-β latency-associated peptide（LAP）,is sufficient to induce modification of latent TGF-β into active TGF-β further facilitating nTreg-mediated suppression.

关 键 词：GARP FOXP3 调节性T细胞 免疫耐受 

分 类 号：R392.11[医药卫生—免疫学]