Toll样受体2、4对病毒囊膜蛋白的识别  

Recognition of viral envelope proteins by Toll-like receptors 2 and 4

作　　者：何小兵[1] 房永祥[1] 贾怀杰[1] 陈国华[1] 曾爽[1] 景志忠[1] 

机构地区：[1]中国农业科学院兰州兽医研究所,730046

出　　处：《免疫学杂志》2011年第10期902-909,共8页Immunological Journal

基　　金：国家自然科学基金项目(30871884);国家高新技术"863"项目(2006AA10A203);转基因生物新品种培育重大专项(2009ZX08008-010B)

摘　　要：TLR2、4是TLRs家族中重要的成员,通过识别囊膜病毒的PAMPs/DAMPs,活化依赖和非依赖于MyD88的信号通路,诱导促炎性细胞因子和趋化因子等的释放,介导先天性抗病毒免疫反应。本文就TLR2、4的基本概况、结构特征、抗病毒信号通路以及对不同囊膜病毒的天然免疫反应等相关研究进展进行简要综述。TLR 2 and 4 are important members of the TLRs family,which are utilized by the innate immune system to recognize viral PAMPs/DAMPs.TLR 2 and 4 play critical roles in initiating innate antiviral immune responses by activating the MyD88 dependent and independent signaling pathway,and leading to induction of proinflammatory cytokines and chemokines.In this review,we focus on the current knowledge of TLR 2 and 4 mediated antiviral innate immune responses to viral infections,including molecular features,antiviral signaling pathway,and antiviral immune responses.

关 键 词：TOLL样受体 先天性免疫 囊膜蛋白 抗病毒免疫 

分 类 号：R392.12[医药卫生—免疫学]