含1,2,3-噻二唑杂环的双酰肼衍生物的合成与杀虫活性  

Synthesis and insecticidal activities of diacylhydrazine derivatives containing 1,2,3-thiadiazole ring

作　　者：Khalema D.L.Thandiwe 石德清[1] 

机构地区：[1]华中师范大学化学学院农药与化学生物学教育部重点实验室,武汉430079

出　　处：《华中师范大学学报（自然科学版）》2011年第3期412-415,443,共5页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金项目(20872046);湖北省自然科学基金项目(2008CDB086)

摘　　要：双酰肼化合物作为一类重要的昆虫生长调节剂广泛用于植物保护中.为了发现新型高效低毒性的双酰肼杀虫剂先导化合物,通过在双酰肼化合物分子骨架中引入1,2,3-噻二唑杂环,设计合成了一类含1,2,3-噻二唑的双酰肼衍生物3,其结构经IR、1 H NMR、ESI-MS和元素分析测试技术确证;生物活性测定结果表明,部分目标化合物在200mg/L质量浓度下对甜菜夜蛾幼虫(spodopteraexigua hubner)和小菜蛾幼虫(plutella xylostella)显示出良好的杀虫活性,如化合物3f对甜菜夜蛾和小菜蛾分别显示出100%和95%的杀死率;但目标化合物对蚜虫(Aphis)的杀死率较微弱.In order to find novel diacylhydrazine insecticide lead compounds with high ac- tivity and low toxicity, a series of novel diacylhydrazine derivatives containing of [1,2, 3]thiadiazole ring were designed and synthesized by introduction of 4-methyl-[1,2,3]th- iadiazole moiety to the diacylhydrazine molecule skeleton. Their structures of the target compounds 3 were confirmed by IR, 1H NMR, ESI-MS and elemental analyses. The results of bioassays showed that some of the title compounds 3 possessed good to excellent insecticidal activities against Spodoptera exigua and Plutella xylostella larvaes, for example, compound 3f displayed 100% and 95% mortality against Spodoptera exigua and Plutella xylostella larvaes at the concentration of 200 mg/L, respectively. Whereas all the title compounds 3 displayed weak insecticidal activity against Aphis at the same concentration.

关 键 词：双酰肼 1 2 3-噻二唑 杀虫活性 

分 类 号：O627.5[理学—有机化学]