急性力竭运动对大鼠肾脏TXA_2/PGI_2代谢平衡的影响  

Effect of Acute Exhaustive Exercise on TXA_2/PGI_2 Metabolism Balance of Renal Tissue in Rats

作　　者：于洋[1] 杨贤罡 王卓涛[3] 周君一 

机构地区：[1]沈阳体育学院,辽宁沈阳110102 [2]河北省体育科学研究所,河北石家庄050001 [3]河北农业大学海洋学院,河北秦皇岛066003

出　　处：《广州体育学院学报》2011年第5期80-83,共4页Journal of Guangzhou Sport University

摘　　要：目的:探讨急性力竭运动及恢复期过程中肾脏TXA2/PGI2代谢平衡调节的生物学效应及自由基代谢的介导作用。方法:SD大鼠随机分为安静对照组、运动后即刻组、运动后1 h组、3 h组和24 h组,各运动组采用递增负荷跑台运动至力竭方案,测定肾组织中TXB2、6-keto-F1α和MDA含量和SOD活性。结果:运动后即刻肾脏TXB2含量和TXB2/6-keto-F1α比值均显著下降,恢复期TXB2含量和TXB2/6-keto-F1α比值均显著低于安静水平。运动及恢复期肾组织SOD活性、MDA含量与TXB2、6-keto-F1α含量均呈显著负相关。结论:力竭运动及恢复期肾脏TXA2/PGI2平衡均下调,运动中有利于维持肾脏局部基本的血液供应,可能与运动性肾脏缺血激发局部代偿机制有关,恢复期则促进肾脏血液再灌注和恢复血供。肾脏抗自由基能力提高可能主要通过抑制肾脏TXA2合成下调TXA2/PGI2平衡。Objective： To explore the biological effect of TXA2/PGI2 metabolism balance and mediate role of free radicals metabolism during acute exhaustive exercise and recovery period. Method： Forty - two SD rats were divided into five groups at random, control group （C, n = 8 ）, immediately after exercise group（ E0, n = 9）, 1 h, 3h and 24h after exercise groups（ E1, n = 9 ; E3, n = 8 ; E24, n = 8 ）. Rats in exercise groups was given an process of incremental loading treadmill running to exhaustive. TXB2, 6 -keto- Flu and MDA content, SOD activity in renal tissue were determinated. Result： TXB2 content and TXB2/6 -keto - F1α ratio in renal tissue significantly decreased immediately after running, while 6 - keto - F1α decreased without statistically significant difference. During recovery period, TXB2 content and TXB2/6 -keto- F1α ratio were still significantly lower than baseline, whereas had no difference with the levels of immediately after running. There was significant negative correlation between TXB2, 6 -keto- F1α content and SOD activity, MDA contents found. Conclusion： The down - regulated of TXA2/PGI2 metabolism was beneficial to renal fundamental blood supply during exercise which may be related to local compensatory mechanism, and also beneficial to renal blood reperfusion and blood supply recovery during recovery period. Increased anti - free radical ability down - regulated TXA2/PGI2 metabolism balance, and this effects may mainly be related to inhibit TXA2 synthesis.

关 键 词：急性力竭运动 肾组织 TXA2/PGI2代谢平衡 自由基代谢 

分 类 号：G804.7[文化科学—运动人体科学]