脑深部神经刺激微电极的表面改性研究  

Surface Modification of Microelectrode for Deep Brain Stimulation

作　　者：白宗旭[1] 刘亚雄[1] 王会友[1] 丁玉成[1] 

机构地区：[1]西安交通大学机械制造系统工程国家重点实验室,西安710049

出　　处：《西安交通大学学报》2011年第10期98-103,共6页Journal of Xi'an Jiaotong University

基　　金：国家自然科学基金资助项目(50875201);国家"863计划"资助项目(2006AA04Z370)

摘　　要：为了提高脑深部刺激电极的生物相容性,降低脑组织的免疫反应,减少或抑制电极周围包裹物的形成,对电极植入端聚氨酯材料进行了表面改性处理.首先用N_2/H_2进行等离子体处理,在电极表面生成活性基团——氨基,再利用电极表面的氨基基团与YIGSR多肽分子发生聚合反应,从而实现在电极表面修饰上对神经细胞具有促进生长作用的多肽分子.改性电极的大鼠植入实验结果发现,改性电极能够在一定程度上减少胶质包裹物的形成,有利于电极与神经细胞之间接触,增加有效刺激体积,证明了电极聚氨酯材料表面接枝聚合生物大分子的可行性,对今后电极表面改性的深入研究具有一定的参考意义.To improve the biocompatibility of micro-electrode for deep brain stimulation （DBS）, and to reduce the immune response of brain tissue and thick encapsulation layer surround the electrode, a surface modification was executed on the polyurethane of DBS electrode head. The electrode surface firstly was modified by N2/H2 plasma treatments to achieve the active amino group, and then the polypeptide molecule YIGSR was endowed by a polymerization with the amino group on the electrode surface, consequently, the electrode surface had a layer of polypeptide molecule promoting nerve cell growth. The experiment results of modified electrode implant in rat brain confirm that to a certain degree, the modified electrode can reduce the thick encapsulation layer surround the electrode, it is beneficial for contact between electrode and never cells, and the electrode can make a bigger volume of tissue activated. The grafting large-molecule polymer on the polyurethane surface is feasible, and the conclusion gets referable for the further research on bioelectrode surface modification.

关 键 词：脑深部刺激 生物电极 等离子体处理 表面改性 

分 类 号：TB39[一般工业技术—材料科学与工程] R608[医药卫生—外科学]