重组人表皮生长因子联合复方磺胺甲噁唑治疗鼻咽癌放射性湿性皮炎32例  

Effect of Recombinant Human Epidermal Growth Factor Combined with Trimethoprim-sulfamethoxazole on Radiodermatitis in 32 Cases of Patients with Nasopharyngeal Carcinoma

作　　者：陈静[1] 陈叶珊[1] 杨坤禹[1] 尹中元[1] 王琼[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肿瘤中心,武汉430022

出　　处：《医药导报》2011年第10期1307-1309,共3页Herald of Medicine

摘　　要：目的观察重组人表皮生长因子溶液联合复方磺胺甲噁唑片外用治疗鼻咽癌患者放射性湿性皮炎的临床疗效。方法根治性放疗中出现3或4度放射性湿性皮炎鼻咽癌患者62例,分为治疗组32例和对照组30例。治疗组患者采用重组人表皮生长因子外用溶液,每10 cm2均匀喷洒创面4 000 U,并将研碎的复方磺胺甲噁唑片粉末均匀撒于创面。对照组患者仅给予重组人表皮生长因子,每10 cm2均匀喷洒创面4 000 U,早晚各一次;两组治疗均至创面彻底干燥,痂皮脱落为止。每日早晚两次定时观察并记录皮损变化及愈合时间,对两组患者的临床疗效和不良反应进行对比观察。结果治疗组的皮损平均愈合时间为3.2 d,对照组平均愈合时间为7.5 d,两组比较差异有统计学意义(P<0.01)。两组患者用药后均未见明显不良反应。结论重组人表皮生长因子联合复方磺胺甲噁唑片局部外用治疗放射性湿性皮炎安全有效,经济易行,可作为鼻咽癌患者放射性湿性皮炎较理想的治疗方法之一。Objective To study the clinical effect of recombinant human epidermal growth factor solution in combination with crushed trimethoprim-sulfamethoxazole tablet for external use on radiodermatitis in nasopharyngeal carcinoma patients. Methods The data of 62 patients with nasopharyngeal carcinoma,who had undergone radical radiotherapy and developed grade 3 to 4 radiodermatitis,were retrospectively analyzed.The treatment goup（n=32） were given recombinant human epidermal growth factor solution at 4 000 U·（10 cm2）-1 plus application of crushed trimethoprim-sulfamethoxazole onto the wound surface,while the patients in the control group（n=30） received only 4 000 U·（10 cm2）-1 of Genetime sprayed onto the wound surface twice a day in the morning and night.In both group,the medicines were used till the wound surface was dry and crust shed off.The change of the radiodermatitis and healing time were observed and recorded at fixed time points twice a day.The efficacy and side effects in the two groups were compared. Results The average healing time of skin desquamation was 3.2 days in the treatment group and 7.5 days in the control group,with difference being statistically significant（P0.01）.No obvious side effect was observed in both groups. Conclusion The treatment of recombinant human epidermal growth factor combined with trimethoprim-sulfamethoxazole for radiodermatitis is safe and effective.

关 键 词：重组人表皮生长因子 磺胺甲噁唑 复方 放射治疗 皮炎 湿性 放射性 

分 类 号：R977.6[医药卫生—药品] R978[医药卫生—药学]