高效液相色谱法测定复方吡拉西坦尼莫地平胶囊中吡拉西坦的含量  

Content determination of piracetam in compound piracetam and nimodipine capasules by HPLC

作　　者：赵建颖 

机构地区：[1]河南洛阳市食品药品检验所,洛阳471023

出　　处：《海峡药学》2011年第9期62-63,共2页Strait Pharmaceutical Journal

摘　　要：目的建立高效液相色谱法测定复方吡拉西坦尼莫地平胶囊中吡拉西坦的含量。方法采用美国Agilent高效液相色谱仪,流动相为甲醇-水（10∶90）,流速1.0mL.min-1,柱温：35℃,检测波长210nm,柱温：35℃。结果吡拉西坦在20.31~203.1μg.mL-1范围内,线性关系良好,r=0.9999,回收率为99.2%。结论本法可准确测定复方吡拉西坦尼莫地平胶囊中吡拉西坦的含量,适用于产品的质量控制。OBJECTIVE To establish a measure to determine the content of piracetam in compound piracetam and nimodipine capasules by HPLC.METHODS Using US Agilent High Performance Liquid Chromatograph Instrument,the mobile phase was methanol-water（10∶90）,the flow rate was 1.0mL·min-1,the UV detection wavelength was 210 nm,the column temperature was 35℃.RESULTS The content of piracetam within the range of 20.31～203.1μg·mL-1 shows a good linearity（r=0.9999） and its recovery is 99.2%.CONCLUSION This method can be used as a measure to determine the exact content of piracetam in compound piracetam and nimodipine capasules and as a control over product quality as well.

关 键 词：吡拉西坦 高效液相色谱 测定 

分 类 号：R927.2[医药卫生—药学]