低氧生理反应的“类推拉效应”实验观察  

Push-pull-like effects of physiological reaction to hypoxia

作　　者：杨军[1] 俞梦孙[1] 李晔[1] 王海涛[1] 曹征涛[1] 张宏金[1] 

机构地区：[1]解放军空军航空医学研究所,北京100142

出　　处：《西南国防医药》2011年第10期1068-1071,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的模拟低氧生理反应的"类推拉效应",即从高氧分压环境快速切换至低氧分压环境时的人体生理反应。方法实验对象为6位青年男性,分别经历由常压常氧和常压50%高氧分压环境阶跃式切换到低氧分压(12.9%,模拟4 km海拔)环境,静坐30 min。整个过程连续测量其血氧饱和度、心率、呼吸波等生理参数。结果 (1)比较由常氧至低氧环境,受试者经历高氧到低氧环境时,SpO2的下降幅度均更显著;(2)氧分压变化时间约2 min;(3)受试者的生理参数反应模式和趋势呈现明显的个体差异。结论证实了自主设计的常压低氧舱的可行性,初步模拟了低氧生理反应的"类推拉效应",观察到一些有价值的现象,为进一步研究以及减轻此类效应对于飞行人员可能造成的不利影响提供了基础数据。Objective To simulate the push-pull-like effects of physiological reaction to hypoxia,viz.the human physiological reaction when the environment is rapidly switched from high oxygen partial pressure to low oxygen partial pressure.Methods Six young male volunteers underwent two kinds of environments,i.e.they were switched from the normal pressure and normoxia condition and the normal pressure and 50% high oxygen partial pressure condition to the low oxygen partial pressure condition（12.9%,simulation of 4 km above the sea level）,respectively.Afterwards,all volunteers sat silently for 30 min.During the whole process,the physiological parameters of these volunteers,such as saturation of blood oxygen,heart rate and respiratory wave,etc,were continuously measured.Results（1） Compared with the condition switched from normoxia to hypoxia,the decrease range of the volunteers＇ SpO2 was more obvious when the environment was switched from hyperxia to hypoxia.（2） The changing time of oxygen partial pressure was 2 min.（3） There were significant individual differences in the volunteers＇ reaction patterns and tendency of physiological parameters.Conclusion The self-designed normal-pressure and hypoxia cabin is feasible.The push-pull-like effects of physiological reaction to hypoxia are simulated preliminarily and some valuable physiological parameters are observed,which provides basic data for further research and alleviating the adverse influence caused by push-pull-like effects on flying personnel.

关 键 词：常压高氧 常压低氧 类推拉效应 血氧饱和度 

分 类 号：R594.3[医药卫生—内科学]