中老年原发性高血压患者血浆同型半胱氨酸水平的临床研究  

The clinical research of plasma homocysteine levels in middle and senile hypertensive patients

作　　者：曹悦鞍[1] 彭朝胜[1] 刘淑云[1] 夏菁[1] 张文洛[1] 谢文秀[1] 杨璐[1] 

机构地区：[1]海军总医院特需医疗部,北京100048

出　　处：《海军总医院学报》2011年第3期136-138,共3页Journal of Naval General Hospital of PLA

摘　　要：目的探讨中、老年原发性高血压患者的血浆同型半胱氨酸(homocysteine,Hcy)水平与高血压的关系。方法选取原发性高血压(高血压组)108例,体检健康者(对照组)60例,对比分析两组体质指数、空腹血糖、血脂等生化指标及血浆Hcy水平;并将两组分别按年龄分为中年组(45岁≤年龄<60岁)和老年组(≥60岁),对比分析各组血浆Hcy水平及高Hcy血症的发病率。结果高血压组血浆Hcy水平(15.19±6.1)μmol/L显著高于对照组(10.76±6.6)μmol/L(P<0.05);无论是高血压组还是正常对照组,老年组血浆Hcy水平均显著高于中年组(P均<0.05);老年高血压组和老年对照组高Hcy血症患病率分别高于中年高血压组和中年对照组(P<0.01、0.05)。结论原发性高血压患者血浆Hcy水平显著高于对照组;随着年龄的增长,血浆Hcy水平也相应升高。提示血浆Hcy与增龄有关,可能参与了高血压的发生、发展过程。Objective To investigate the relationship between the plasma homocysteine（Hcy） levels and the blood pressure in middle and senile primary hypertensive patients.Methods One hundred and eight primary hypertensive patients（hypertensive group） and 60 healthy individuals（control group） were divided into two groups according to age：the middle group（MG） from 45 to 60 years old,the senile group： above 60 years old respectively.Body mass index,fasting blood glucose,blood lipids and the plasma Hcy levels were measured.The plasma Hcy levels and the incidence of high hyperlipidemia（HHcy） were compared.Results The Hcy levels were higher in hypertensive group（15.19±6.1）μmol/L than control group（10.76±6.6）μmol/L（P0.05）.The homocysteine levels in senile hypertensive group was the highest.Both the incidences of HHcy in senile hypertensive group and senile control group were higher than middle hypertensive group and middle control group（P0.01,0.05 respectively）.Conclusion The plasma Hcy levels increased with age increasing.Hcy may play a role in the initiation and developing of primary hypertension.

关 键 词：高血压 同型半胱氨酸 中老年人 

分 类 号：R544[医药卫生—心血管疾病]