中药联合尿多酸肽治疗血液肿瘤疾病作用机制浅析  

Analysis of Mechanisms of Using Traditional Chinese Medicine Combined with Uroacitides for Treating Neoplastic Hematologic Disorders

作　　者：田杰[1] 陈信义[2] 李冬云[2] 许亚梅[2] 

机构地区：[1]贵阳中医学院基础部,贵州贵阳550002 [2]北京中医药大学东直门医院血液肿瘤科,北京100700

出　　处：《中医学报》2011年第10期1153-1155,共3页Acta Chinese Medicine

基　　金：北京东直门医院自主创新课题(编号:2009001)

摘　　要：目的:探讨尿多酸肽(cell differentiation Agent,CDA-2)治疗血液肿瘤疾病的作用机制。方法:通过例举中药复方制剂联合CDA-2治疗AML、MDS的典型病案,分析CDA-2治疗血液肿瘤疾病的作用机制。结果:CDA-2作为甲基转移酶抑制剂,联合中药复方制剂治疗AML、MDS,疗效肯定,可改善临床症状,提高生活质量。结论:CDA-2治疗血液肿瘤疾病,可能是通过诱导肿瘤细胞分化、凋亡、逆转耐药等机制而发挥作用。Objective：To investigate the mechanism of CDA-2 for the treatment of neoplastic hematologic disorders.Methods：Mechanism of CDA-2 for treating neoplastic hematologic disorders was analyzed by presenting typical cases of using Chinese patent compound medicine combined with CDA-2 to treat AML and MDS.Results：CDA-2 as a methyltransferase inhibitor combined with Chinese patent compound medicine showed definite curative effects,which could improve clinical symptoms and improve quality of life.Conclusion：The role of using CDA-2 in treating neoplastic hematologic disorders is possibly exerted through induction of tumor cell differentiation,apoptosis,reversal of drug resistance and other mechanisms.

关 键 词：尿多酸肽 血液肿瘤 作用机制 复方浙贝颗粒 益髓颗粒 

分 类 号：R285.6[医药卫生—中药学]