精油对全麻大鼠促醒效应的实验研究  

Effects of essential oils on wake-promoting of general anesthesia in rats

作　　者：方文恒[1] 徐金勇[1] 任振华[1] 李光武[1] 

机构地区：[1]安徽医科大学神经生物研究所,安徽合肥230032

出　　处：《安徽医药》2011年第11期1338-1340,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金(No81000589);安徽省自然科学基金(No090413145)

摘　　要：目的研究精油对全麻的促醒效果。方法该研究选用了PM、迷迭香、薰衣草精油及三种全麻药戊巴比妥钠、丙泊酚和氯胺酮,通过吸嗅器械分别观察了:吸嗅PM、迷迭香(RM)、薰衣草(LA)精油对戊巴比妥钠全麻大鼠睡眠时间的影响;不同吸嗅浓度的薰衣草精油是否改变戊巴比妥钠(PTB)全麻大鼠的睡眠时间以及吸嗅PM精油分别对丙泊酚(PRO)和氯胺酮(KET)全麻大鼠睡眠时间的影响。结果 PM精油可明显降低戊巴比妥钠和丙泊酚诱导的睡眠时间,而对氯胺酮则无明显效果;薰衣草精油在给定吸嗅浓度下也存在促醒效果。结论吸嗅PM精油和特定浓度的薰衣草精油对全麻大鼠具有促醒效应。Aim To research the effects of essential oils on wake-promoting of general anesthesia.Methods Three kinds of essential oil PM,rosemary,lavender oil and three kinds of anesthetics pentobarbital（PTB）,propofol（PRO）,ketamine（KET） were used in our study.We investigated the effects of PM,rosemary,lavender oil on PTB-induced general anesthesia,whether various concentrations of lavender oil affected PTB-induced general anesthesia and the effects of PM oil on PRO,KET-induced general anesthesia.Results It indicated that PM oil reduced PTB and PRO-induced general anesthesia duration significantly while the anesthesitic KET had no significant effect.In addition,lavender oil had wake-promoting effect in given concentration.Conclusion It could have wake-promoting effect of general anesthesia in rats by inhalation of PM oil and lavender oil in given concentration.

关 键 词：全麻促醒 精油 吸嗅 嗅觉通路 LORR TIME 

分 类 号：R285.5[医药卫生—中药学]