金荞麦对家鸽气管纤毛运动和豚鼠离体气管平滑肌舒张的影响  

Effect of Jinqiaomai on the columba livia domestica trachea ciliary movement and the guinea pig in vitro tracheal smooth muscle

作　　者：高世乐[1] 汪春彦[1] 江勤[1] 张志芬 董六一[1] 

机构地区：[1]安徽医科大学药理学教研室抗炎免疫药理学省部共建教育部重点实验室国家中医药管理局中药药理三级实验室,安徽合肥230032 [2]南通精华制药股份有限公司,江苏南通226005

出　　处：《安徽医药》2011年第11期1346-1348,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的研究金荞麦对家鸽纤毛运动和豚鼠离体气管平滑肌舒张的影响。方法气管纤毛运动试验观察不同剂量金荞麦(6,3,1.5 g生药/kg)对家鸽纤毛运动的影响;制备新鲜的豚鼠离体气管片,在K-H缓冲液中观察不同剂量的金荞麦(累积浓度为15,30,60,120 g生药/L)对气管片收缩的影响;制备新鲜的豚鼠离体气管螺旋条,在K-H缓冲液加入组胺,使豚鼠气管螺旋条收缩达高峰后观察不同剂量的金荞麦(15,30,60,120g生药/L)对组胺致气管片收缩的影响。结果金荞麦三个剂量组均能加快家鸽气管内纤毛运动速度(P<0.01或P<0.05);金荞麦60～120 g生药/L溶液能明显松弛正常豚鼠离体气管平滑肌(P<0.01或P<0.05);金荞麦15～120 g生药/L溶液对组胺致豚鼠离体气管平滑肌收缩有明显解痉作用(P<0.01)。结论金荞麦可明显加快家鸽气管纤毛运动;金荞麦可明显松弛豚鼠离体气管平滑肌,并具有一定的浓度依赖性;并对组织胺致豚鼠离体气管平滑肌收缩有明显解痉作用,并呈现一定的浓度依赖性。Aim To study the effect of Jinqiaomai（JQM） on the columba livia domestica trachea ciliary movement and the relaxation of the guinea pig in vitro tracheal smooth muscle.Methods The tracheal ciliary movement experiment was made to observe the effect of different dosages of JQM（6,3,1.5 g dried medicinal herb /kg） on the columba livia domestica trachea ciliary motility.The fresh piece of guinea pig trachea was prepared to,observe the effect of different dosages of JQM（cumulative concentration of 15 g dried medicinal herb/L,30g dried medicinal herb/L,60 g dried medicinal herb/L,120 g dried medicinal herb/L） on the fresh piece of guinea pig trachea in K-H buffer solution.Fresh tracheal spiral strips of guinea pig were prepared to observe the effect of different dosages of JQM（cumulative concentration of 15g dried medicinal herb/L,30 g dried medicinal herb/L,60 g dried medicinal herb/L,120g dried medicinal herb/L） on the tracheal spiral strips excite by histamine in the K-H buffer solution.Results The three groups of JQM could step-up the tracheal ciliary movement of the columba livia domestica（P0.01 or P0.05）;the 60~120 g dried medicinal herb /L solution could significantly relax the tracheal smooth muscle in vitro of the normal guinea pig（P0.01 or P0.05）;the 15~120 g dried medicinal herb /L solution,to the histamine induced contraction of isolated guinea pig tracheal smooth muscle,had significant spasmolysis effect（P0.01）.Conclusions JQM can significantly speed up the pigeon＇s tracheal ciliary movement.JQM can significantly relax the isolated tracheal smooth muscle of guinea pig,and depend on the concentration,and to the histamine induced contraction of the isolated tracheal smooth muscle of guinea pig has a significant spasmolysis effect showing dependence on the concentration to some extent.

关 键 词：金荞麦 气管平滑肌 纤毛运动 

分 类 号：R285.5[医药卫生—中药学]