阿托伐他汀对冠状动脉慢血流治疗作用的疗效观察  

Effect of atrovastatin on the patients wit coronary slow artery flow phenomenon

作　　者：阮爱兵[1] 吕爱玲[1] 王锦乾 方五旺[1] 王永[1] 杨俊平[1] 杨洋[1] 

机构地区：[1]安徽省芜湖市第二人民医院,安徽芜湖241000 [2]山东省威海市市立二院

出　　处：《华北煤炭医学院学报》2011年第5期595-596,共2页Journal of North China Coal Medical College

摘　　要：①目的观察阿托伐他汀对冠状动脉慢血流患者的临床疗效。②方法冠状动脉慢血流患者31例,随机分为两组,观察组给予阿托伐他汀联合常规治疗(16例),常规治疗组给予单硝酸异山梨酯+阿司匹林常规治疗(15例)。选取年龄、性别、心血管危险因素等匹配而冠脉血流正常的22例患者为正常对照组。③结果两组患者对比,观察组患者胸痛等不适改善优于常规治疗组,存在血流缓慢的前降支、回旋支、右冠脉的基础TFC值观察组分别为50.1±15.6、60.2±12.4、55.9±13.8,常规治疗组分别54.1±11.6、58.2±10.4、61.9±14.8,正常对照组分别为18.1±10.6、20.2±13.4、22±13.8;观察组治疗后TFC值分别下降至34.1±12.6、36.2±16.4、33.9±15.8(与基础状态比较,均P<0.01),常规治疗组治疗后TFC分别下降至42.1±10.5、45.2±14.3、39.9±11.6(与基础状态比较,均P<0.05),但仍均高于正常对照组(与基础状态比较,均P<0.05)。④结论阿托伐他汀治疗对冠状动脉慢血流患者有益。Objective To assess the clinical effect of atrovastatin on the patients with coronary slow flow phenomenon（CSFP）.Methods 31 patients with CSFP without stenotic lesions during diagnostic coronary angiogray were enrolled and divided into trial group and routine administration group randomly.The trial group was treated with atrovastatin combined with aspirin＋isosorbide mononitrate＋ atrovastatin,and the routine administration group was treated only with aspirin＋isosorbide mononitrate.22 patients with normal coronary flow served as normal control.Results Clinical characteristics were similar among the three grops.The basic TFCs of left anterior descending artery（LAD）,left circumflex artery（LCX） and right coronary artery（RCA）were（50.1±15.6）、（60.2±12.4）、（55.9±13.8） in the trial group,and were respectively（54.1±11.6）、（58.2±10.4）、（61.9±14.8）in the routine group,which wer signiccantly higher than those in the normal controls（18.1±10.6、20.2±13.4、22±13.8）.After the administration for 6 months,the TFCs of LAD,LCX AND RCA were respectively（34.1±12.6）、（36.2±16.4）、（33.9±15.8）（all P0.01 vs.basline）in the trial group and were（42.1±10.5）、（45.2±14.3）、（39.9±11.6）（all P0.01 vs.basline）in the routine group.The TFCs after admimistration in both therapy groups were significantly higher than that in normal controls（all P0.05）.Conclusion The effect of atrovastatin was effective to the patients with CSFP.

关 键 词：阿托伐他汀 冠状动脉造影 冠状动脉慢血流 

分 类 号：R541.4[医药卫生—心血管疾病]