微波辅助的一步法合成异黄酮化合物  

"One pot" Synthesis of Isoflavones under Microwave Irradiation

作　　者：冯海[1] 元永波[2] 孟彦和[2] 刘利军[2] 

机构地区：[1]宁夏广播电视大学,宁夏银川750001 [2]宁夏大学化学化工学院,宁夏银川750021

出　　处：《宁夏大学学报（自然科学版）》2011年第3期252-254,共3页Journal of Ningxia University(Natural Science Edition)

基　　金：宁夏科技攻关基金资助项目([2010]168号)

摘　　要：以苯乙酸和酚类化合物为主要原料,在微波辅助下,以BF3-Et2O为催化剂,DMF-PCl5为关环试剂,用改进的"一锅煮"法,一步高产率地合成了7,4’-二羟基异黄酮,7-羟基异黄酮,4’,5,7-三羟基异黄酮和5,7-二羟基异黄酮.与传统转化方法相比,该方法简单、快速和经济.Daidzein,Genistein,7-hydroxyisoflavones and 5,7-dihydroxyisoflavones are synthesized by using improve one-pot procedure from the polyhydric phenol and hydroxysubstituted phenyl acetic acid catalyzed by boron-etherate under microwave irradition with good yields.Their structures are confirmed by 1H-NMR,IR,MS spectra and element analysis.Compared with the conventional method,it is simple,rapid and eco-friendly.

关 键 词：微波 一步合成 羟基异黄酮 

分 类 号：O625.4[理学—有机化学]