异甘草素及其类似物的合成  

Synthesis of Isoliquiritigenin and Its Derivatives

作　　者：杨金诚[1] 元永波[1] 刘利军[1] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《宁夏大学学报（自然科学版）》2011年第3期255-257,265,共4页Journal of Ningxia University(Natural Science Edition)

基　　金：宁夏科技攻关基金资助项目([2010]168号)

摘　　要：以2,4-二羟基苯乙酮和取代苯甲醛为原料,在微波辅助下,以KOH为催化剂,以C2H5OH为溶剂,较高产率(65%～89%)合成了10种异甘草素及其类似物.经1 H-NMR,IR,MS波谱分析确定了合成化合物的结构,并分别考察了辐射功率、辐射时间、反应的原料配比以及溶剂用量等因素对反应产率的影响.Isoliquiritigenin and its derivatives（3a～3j）are synthesized in ethanol from 2,4-dihydroxyacetophenone and substituted benzaldehyde under microwave with KOH as catalyst with yields of 65% to 89%.Their structures are characterized by 1H-NMR,IR,MS spectra,The factors such as temperature,material ratio,the amount of solvent,the microwave irradiation power and time will affect the yield of Isoliquiritigenin and its derivatives.

关 键 词：异甘草素 微波辐射 Claisen—Schmidt缩合 合成 

分 类 号：O622.4[理学—有机化学]