对乙酰氨基酚/β-环糊精包合物的电化学与荧光光谱学研究  

Electrochemical and Fluorescence Spectral Study on Inclusion Complexes of p-Acetaminophen with β-Cyclodextrin

作　　者：张宏[1] 

机构地区：[1]宁夏职业技术学院,宁夏银川750021

出　　处：《宁夏大学学报（自然科学版）》2011年第3期258-261,共4页Journal of Ningxia University(Natural Science Edition)

基　　金：国家"973"前期预研基金资助项目(2006CB708606);宁夏自然科学基金资助项目(2004-CD01)

摘　　要：用循环伏安法(cyclic voltammetry,CV)研究对乙酰氨基酚(p-acetaminophen,p-ACOP)与β-环糊精(β-cy-clodextrin,β-CD)包合物的电化学行为,并用电位法和电流法测定了包合物的包合比和包合常数.结果表明,p-ACOP与β-CD形成1∶1型包合物,包合常数Kb=1.67×102 L/mol,与荧光光谱法所得结果一致.p-ACOP与β-CD发生包合作用后,对p-ACOP的电化学氧化具有较强的抑制作用,同时提高了p-ACOP的稳定性.为拓宽p-ACOP在医药工业中的使用范围提供参考.To investigate the electrochemical behaviors of inclusion complex between p-acetaminophen（p-ACOP）and β-cyclodextrin（β-CD）.The inclusion ratio and inclusion constant are also calculated.The inclusion complex of p-acetaminophen（p-ACOP）with β-cyclodextrin（β-CD）have been studied by cyclic voltammetry（CV）.The inclusion ratio and inclusion constant of p-ACOP with β-CD are determined by potential and current methods.The experimental results of the inclusion complexes are complied with Fluorescence Spectra（FS）.The inclusion number of p-ACOP with β-CD is 1∶1,and the inclusion constant is 1.67×102 L/mol,which are similar to the values of Fluorescence Spectra method.It was observed from the experiments that the strong inclusion is existed between p-ACOP and β-CD.The results show that the electrochemical oxidation of p-ACOP is inhibited by β-CD,which can be improved the stability and also provided the theoretic evidence for widening its application in pharmaceutical industry.

关 键 词：对乙酰氨基酚 环糊精 包合物 电化学 荧光光谱 

分 类 号：O647[理学—物理化学]