亚健康状态老年人血白细胞介素18和白细胞介素10水平变化及意义  

Study on plasma interleukin 18 and serum interleukin 10 in elderly people with sub-health

作　　者：王淑斐[1] 许金成[1] 程明刚[1] 

机构地区：[1]南方医科大学附属深圳宝安人民医院体检中心,广东省深圳市518101

出　　处：《实用老年医学》2011年第5期388-389,392,共3页Practical Geriatrics

基　　金：深圳市科技计划项目(200803228)

摘　　要：目的探讨白细胞介素18(IL-18)、白细胞介素10(IL-10)在老年亚健康状态发生发展中的作用及相互关系。方法应用酶联免疫吸附法测定45例亚健康状态老年人(≥60岁)血浆IL-18和血清IL-10水平,以42例亚健康状态老年前期(50～59岁)和30例健康老年人(≥60岁)作比较,分析它们之间的关系。结果亚健康状态老年人血浆IL-18水平显著高于健康老年人(P<0.01),以及亚健康老年前期组(P<0.05),血清IL-10水平则显著低于对照组(P<0.01)和老年前期组(P<0.05);血浆IL-18水平与血清IL-10水平之间呈负相关(r=-0.882,P<0.01)。结论 IL-18和IL-10可能共同构成一局部网络,并可能参与亚健康状态的发生发展过程。Objective To study the changes of plasma interleukin 18（IL-18） and serum interleukin 10（IL-10） in the elderly people with sub-health （SH） and the clinical significance.Methods The plasma level of IL-18 and serum level of IL-10 in 45 elderly people with SH were measured by enzyme linked immune sandwich assay （ELISA）,42 prevenient elderly people with SH and 30 healthy elderly persons（HEP） were enrolled as control.The relationships of IL-18 and IL-10 with SH were analyzed.Results The level of IL-18 in elderly people with SH was significantly higher than that in HEP（P〈0.01）,and that in prevenient elderly people with SH（P〈0.05）.The level of IL-10 in elderly people with SH was significantly lower than that in HEP（P〈0.01）,and that in prevenient elderly people with SH（P〈0.05）.The level of IL-18 in elderly people with SH was negatively correlated with the level of IL-10（r=-0.882,P〈0.01）.Conclusions The cytokine network constructed by IL-18 and IL-10 may be involved in the pathogenesis and development of sub-health.

关 键 词：亚健康 白细胞介素18 白细胞介素10 老年 

分 类 号：R392.11[医药卫生—免疫学]