可调式胃电刺激器的不同参数对比格犬的摄食调节作用  

Effects of adjustable gastric electrical stimulator with different parameters on the food intake of Beagle dogs

作　　者：李艳梅[1,2] 姚树坤[2] 赵洪川[2] 张艳丽[2] 姚力[2] 陈少轩[2] 张伟硕[2] 郭文娟[2] 杜时雨[2] 房龙[2] 

机构地区：[1]北京协和医学院研究生院,北京100730 [2]中日友好医院消化内科,北京100029

出　　处：《中日友好医院学报》2011年第5期285-289,共5页Journal of China-Japan Friendship Hospital

基　　金：国家自然科学基金资助;项目号81070299;首都医学发展科研基金资助;项目号2001-2018

摘　　要：目的:建立比格犬胃造瘘及胃电刺激器植入模型,观察胃电刺激对摄食量的影响,并筛选能够抑制犬摄食量的胃电刺激参数。方法:对8只比格犬进行了胃造瘘及可调式胃电刺激器的植入,每只动物进行假刺激及波宽为0.3～9ms不同参数的胃电刺激。观察胃电刺激下犬摄食量及症状的变化,筛选有效刺激参数。结果:胃电刺激可显著减少犬的摄食量,无严重并发症出现。每只犬的有效刺激参数呈现明显的个体化。结论:胃电刺激治疗肥胖需要采用个体化的刺激参数,可调式胃电刺激器较传统的胃电刺激器更有优势。Objective：To establish the effects of adjustable gastric electrical stimulation（GES）on the food-intake and deriving the optimal parameters in a canine model.Methods：Eight dogs were each implanted with a gastric cannula and an adjustable stimulator.GES with trains of short-pulses：10mA,2s-on,3s-off,40Hz and a series of pulse widths（0.3ms～9ms）were performed.Food intake and symptoms during acute GES were observed to find the most effective parameters.Results：GES may significantly inhibit beagle dogs＇food intake without causing any serious complication.The effective parameters vary greatly among the subject beagle dogs to demonstrate remarkable distinctions for each dog.Conclusion：The parameters of GES should be individualized in treating obesity and adjustable GES may have an advantage over the traditional GES.

关 键 词：胃电刺激 摄食 参数 肥胖 

分 类 号：R589.2[医药卫生—内分泌]