山楂叶总黄酮对缺血性脑卒中活血化瘀作用研究  

Flavone Mixture of Crataegus Leaves on Promoting Blood Circulation by Removing Blood Stasis

作　　者：胡敏[1] 张晓丹[1] 涂映 陈敏[1] 万云辉[1] 

机构地区：[1]江西护理职业技术学院,南昌330029

出　　处：《实用中西医结合临床》2011年第5期1-3,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江西省卫生厅基金项目(编号:20093154)

摘　　要：目的:探讨山楂叶总黄酮(FMCL)对缺血性脑卒中的活血化瘀作用。方法:采用皮下注射肾上腺素造成大鼠血瘀模型,观察山楂叶总黄酮对全血黏度、血浆黏度的影响;采用体内电刺激血栓形成法,观察山楂叶总黄酮对体内血栓形成时间的影响;观察山楂叶总黄酮对ADP诱导的血小板聚集的影响。结果:与模型组比较,FMCL能改善血瘀大鼠血液流变学的异常变化,FMCL(60mg/kg、30mg/kg)明显降低全血黏度及血浆黏度,能明显延长电刺激所致的血管内血栓的形成时间,对血小板聚集有一定的抑制作用(P<0.05,P<0.01)。结论:山楂叶总黄酮通过改变血液流变学状态、降低全血黏度、降低血小板的聚集性、抑制血栓形成,使脑组织的损伤减轻。Objective：To study the protective effect of flavone mixture of crataegus leaves（FMCL）on promoting blood circulation by removing blood stasis on ischemic stroke.Methods：The subcutaneous injection of adrenaline caused blood stasis model rats,observation of FMCL on whole blood viscosity and plasma viscosity.Using in vivo electrical stimulation of thrombus formation method,observation of FMCL on thrombus formation in vivo effect of time and platelet aggregation induced by ADP effect.Results：Compared with the model group,FMCL can improve blood stasis rat blood rheology changes.FMCL（60 and 30 mg/kg） decreased dignificantly blood viscosity and plasma viscosity.Prologed electrical stimuation induced intravascular thrombus formation time.On platelet aggregation have certain inhibition effect（P〈0.05,P〈0.01）.Conclusion：Flavone mixture of crataegus leaves through changes in blood rheology,the reduction of blood viscosity,reduce platelet aggregation,inhibition of thrombosis,make the injured brain tissue loss.

关 键 词：山楂叶总黄酮 缺血性脑卒中 活血化瘀 

分 类 号：R285.5[医药卫生—中药学]