米索前列醇不同给药途径用于绝经后妇女取器的临床研究  

Clinical analysis on different administration route of Misoprostol for removal of intrauterine devices in postmenopausal women

作　　者：景秀 尹淑 

机构地区：[1]重庆市人口和计划生育科学技术研究院计划生育科,重庆400020 [2]重庆市长寿区生殖健康中心计划生育科,重庆401220

出　　处：《中国计划生育和妇产科》2011年第5期62-64,共3页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的观察米索前列醇不同给药途径用于绝经后妇女宫内节育器(intrauterine contraceptivedevice,IUD)取出术的效果。方法采用随机对照前瞻性研究方法,于术前2～4h应用米索前列醇400μg分别口服给药、阴道给药、舌下含化给药,观察宫颈软化情况和取器效果。结果宫颈软化率和取器成功率各组间差异均无统计学意义(P>0.05)。结论米索前列醇3种给药途径用于绝经后妇女取器的宫颈软化率和取器成功率无差异,口服给药有胃肠道反应,阴道给药易被稀释和冲出,影响药物吸收,故选择舌下含化给药更简便、安全和易行,值得临床推广。Objective To study the efficacy of different administration routes of Misoprostol for removal of intrauterine contraceptive devices（IUD） in postmenopausal women. Methods A prospective randomized controlled study was conducted on 400μg of Misoprostol administered through oral, vaginal or sublingual respectively two to four hours before surgery. The data of cervix softening and efficacy of IUD removed were observed and analyzed. Results The difference about cervix softening rate and success rate of IUD removed among groups was significant respectively （ P 〉 0. 05 ）. Conclusion The difference was no significant on cervix softening rate and success rate of IUD removed among three administration route of Misoprostol for postmenopausal women. Oral administration of Misoprostol is easily to have gastrointestinal tract reactions. Vaginal administration of Misoprostol was easily diluted or rushed out, and affected drug absorption. Sublingual administration was more convenient and safe so that it is worthy to be popularized.

关 键 词：米索前列醇 绝经 宫内节育器取出术 给药途径 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]