乙型肝炎病毒前S1抗原检测的临床价值  

Clinical value of HBV PreS1-Ag detection

作　　者：杨崎恩[1] 蒋亦明[1] 陆宇红[1] 

机构地区：[1]无锡市传染病医院传染科二病房,江苏无锡214000

出　　处：《现代医药卫生》2011年第19期2896-2897,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨乙型肝炎(简称乙肝)患者血清HBV PreS1-Ag、HBV-DNA、HBeAg之间的相关性及临床意义。方法:60例慢乙肝患者均为HBsAg阳性,用全自动酶免仪检测HBV PreS1-Ag及HBeAg,用PCR法检测HBV-DNA。结果:60例HBsAg阳性慢乙肝患者中,HBV PreS1-Ag的检出率为58.3%,HBV-DNA的检出率为61.6%,HBeAg的检出率为35%。HBV PreS1-Ag的检出率明显高于HBeAg的检出率,差异有统计学意义(P<0.05);HBV-DNA的检出率亦明显高于HBeAg的检出率,差异有统计学意义(P<0.05);HBVPreS1-Ag和HBV-DNA的检出率相似,差异无统计学意义(P>0.05)。结论:HBV PreS1-Ag和HBV-DNA在乙肝患者血清中有相似的检出率,较HBeAg更能反映乙肝患者血液中HBV的复制情况。Objective：To analyze the correlation among HBV PreS1-Ag,HBV-DNA and HBeAg in hepatitis B patients and its clinical significance. Methods：60 patients with chronic hepatitis B and positive HBsAg were detected HBV PreS1-Ag and HBeAg by automatic ELISA,and HBV-DNA by PCR. Results：Among 60 patients with HBsAg-positive chronic hepatitis B,HBV PreS1-Ag detection rate was 58.3%,HBV-DNA detection rate was 61.6% and HBeAg positive rate was 35%. The detection rate of HBV PreS1-Ag was significantly higher than that of HBeAg with statistical difference between them （P〈0.05）.The detection rate of HBV-DNA was also significantly higher than that of HBeAg,showing statistical difference between them （P〈0.05）. The detection rate of HBVPreS1-Ag and HBV-DNA was similar without statistical difference between them （P〉0.05）.Conclusion： HBV PreS1-Ag and HBV-DNA have a similar detection rate in serum of the patients with hepatitis B,which can better reflect the replication of HBV in blood of hepatitis B patients.

关 键 词：HBV PRES1-AG HBV—DNA HBEAG 

分 类 号：R446[医药卫生—诊断学]