不同方法对黄连小檗碱的纯化比较研究  

Comparative study on purification of berberine in rhizoma of Coptis chinensis Franch by different ways

作　　者：席国萍[1] 宋国斌[1] 

机构地区：[1]山西大同大学医学院,山西大同037009

出　　处：《现代医药卫生》2011年第19期2901-2903,共3页Journal of Modern Medicine & Health

摘　　要：目的:比较大孔吸附树脂和液液萃取两种方法对黄连小檗碱的纯化效果,为开发利用黄连小檗碱提供参考。方法:采用大孔吸附树脂法和液液萃取两种方法。结果:以标准品盐酸小檗碱为对照,大孔吸附树脂在产品重量和产品中小檗碱含量方面均明显高于液液萃取,其中D101大孔吸附树脂对黄连小檗碱有较好的纯化效果,产品中小檗碱含量达29.82%。结论:黄连小檗碱为传统中药材黄连的主要成分,在抗菌消炎、心血管疾病治疗等方面显示出良好的治疗效果。具有广阔的应用前景。Objective：To compare the purification effects of berberine in rhizoma of Coptis chinensis Franch by the liquid-liquid extraction and the macroporous adsorption resin to offer reference for its development and utilization. Methods：The macroporous adsorption resin and the liquid-liquid extraction were used to extract berberine. Results：Using berberine hydrochloride as control, the macroporous adsorption resin was higher than the liquid-liquid extraction in terms of the product weight and the content of berberine in product. The D101 macroporous adsorption resin had a good effect on the purification of berberine in rhizoma of Coptis chinensis Franch and the content of berberine in product reached to 29.82%. Conclusion：Berberine as the main component of traditional Chinese medicinal material rhizoma of Coptis chinensis Franch demonstrates better effects in antiblosis, diminishing inflammation and treating cardiovascular diseases, which possesses extensive application prospects.

关 键 词：黄连 小檗碱 纯化 

分 类 号：R28[医药卫生—中药学]