2008-2010年结核分枝杆菌的耐药性分析  

Analysis of antibiotics resistance of Mycobacterium tuberculosisduring 2008-2010

作　　者：王湘[1] 张丽霞[1] 

机构地区：[1]天津市海河医院医院感染管理科,天津300350

出　　处：《中华医院感染学杂志》2011年第20期4394-4395,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解2008-2010年结核患者分离出的结核分枝杆菌对常用抗结核药物的耐药性变迁。方法采用罗氏培养系统进行结核分枝杆菌培养,药敏试验采用绝对浓度法,回顾性分析天津市海河医院分离的455株痰结核分枝杆菌的耐药性。结果 455株结核分枝杆菌对链霉素、左氧氟沙星、利福平、乙胺丁醇、异烟肼、阿米卡星、对氨基水杨酸的总耐药率分别为29.2%、24.6%、23.1%、18.2%、18.5%、13.4%、9.2%。结论结核分枝杆菌的耐药率仍然较高,规范、足量、联合用药,是减缓耐药率的主要途径。OBJECTIVE To investigate the variance of antimicrobial resistance and drug susceptibility of seven anti-TB drugs in hospitalized tuberculosis patients during 2008-2010.METHODS Roche system was used to culture Mycobacterium tuberculosis and absolute concentration method was used to test the drug susceptibility.Drug resistance and variance of antimicrobial resistance rates of 455 strains were retrospectively analyzed.RESULTS Of 455 strains,the total drug resistance rates of streptomycin,levofloxacin,rifampicin,ethambutol,isoniazid,amikacin,para-aminosalicylic acid were 29.2%,24.6%,23.1%,18.2%,18.5%,13.4% and 9.2%,respectively.CONCLUSION The resistance rate of M.tuberculosis is still high.Standard,united,full course of treatment medication is still the main way to reduce the drug resistance.

关 键 词：结核分枝杆菌 药敏试验 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]