雄黄超高压射流粉表征及抑菌效果  

Characterization and Antibacterial Effect of Realgar Ultra-high Pressure Jet Powder

作　　者：黄义娜[1] 王盛民[1] 詹源文[1] 张瑛[2] 罗兰[1] 王懿萍[1] 张小荣[1] 陈波 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]陕西中医学院,陕西咸阳712083 [3]南京大地水刀有限公司,南京211300

出　　处：《中国实验方剂学杂志》2011年第20期21-23,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：陕西省咸阳市项目(XK0913-2);成都市金牛区[金科产发(2008)64]

摘　　要：目的:研究经超高压射流粉碎后雄黄表征差异,探讨粉体粒径对抑菌效果的影响。方法:利用超高压射流技术对雄黄进行粉碎,比较雄黄普通粉、水飞粉和射流粉的粉体表征、体外抑菌效果。结果:雄黄粉体平均粒径由23.756μm降到1.427μm,比表面积由1.251 m2.cm-3增至11.653 m2.cm-3,休止角增大,松密度降低,主要成分无明显变化;对大肠杆菌最低抑菌浓度(MIC)由8%降到2%,对金黄色葡萄球菌MIC由1%降到0.5%。结论:雄黄经超高压射流技术粉碎后,粒径明显减小,比表面积显著增大,孔隙率大大增大,流动性变差,主要成分符合《中国药典》规定,体外抑菌效果与粉体粒径大小呈负相关。超高压射流技术用于雄黄粉碎是可行的。Objective： To study characterization difference of Realgar after smashed by ultra-high pressure jet and investigated the influence of particle size to antibacterial effect.Method： Smashed Realgar by ultra-high pressure jet technology,and compared powder characterization and in vitro antibacterial effect of ordinary powder,levigating powder and jet powder of Realgar.Result： Compared with ordinary powder and levigating powder,average particle size of jet powder reduced from 23.756 μm to 1.427 μm,specific surface area increased from 1.251 m2·cm-3 to 11.653 m2·cm-3,angle of repose increased,and bulk density decreased,main chemical composition had no significant change;Minimum inhibitory concentration（MIC） to escherichia coli reduced from 8% to 2%,MIC to staphylococcus aureus reduced from 1% to 0.5%.Conclusion： After smashed by ultrahigh pressure jet,particle size of Realgar ultra-high pressure jet powder reduced significantly,specific surface area significantly increased,porosity increaseed greatly,liquidity got worse,main chemical composition of the powder complied with pharmacopoeial requirement,in vitro antibacterial effect and powder particle size was negatively correlated.The result showed that smashed Realgar by ultra-high pressure jet was feasible.

关 键 词：超高压射流 雄黄 表征 抑菌效果 

分 类 号：R283.6[医药卫生—中药学]