山茱萸纳米软胶囊的制备及含量测定  

Preparation and Content Determination of Corni Fructus Soft Nanocapsule

作　　者：张乐[1] 李兴华[1] 马小亚[1] 雷建林[1] 

机构地区：[1]西安交通大学医学院第二附属医院药剂科,西安710004

出　　处：《中国实验方剂学杂志》2011年第20期30-32,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:制备山茱萸纳米软胶囊并建立含量测定方法。方法:采用薄膜-超声法制备山茱萸纳米混悬液,高效液相色谱法测定其脂溶性成分熊果酸、水溶性成分马钱苷的含量。结果:熊果酸进样量在1.132～5.660μg有良好线性关系(r=0.999 7),平均回收率98.90%,RSD 1.85%;马钱苷进样量在0.176～0.880μg有良好线性关系(r=0.999 7),平均回收率99.12%,RSD 1.26%。结论:该方法操作简便、灵敏度高、结果准确,可作为山茱萸纳米软胶囊的质量控制方法。Objective： Prepared corni fructus soft nanocapsule and determine the content.Method： Prepared corni fructus nanosuspension by film-ultrasonic wave dissolving techniques.Determined ursolic acid of liposoluble components and loganin of water-soluble components by HPLC.Result： The linear range of ursolic acid was 1.132-5.660 μg（r=0.999 7）.The average recovery was 98.90% with RSD 1.85%.The linear range of loganin was 0.176-0.880 μg（r=0.999 7）.The average recovery was 99.12% with RSD 1.26%.Conclusion： This method is simple,sensitive and accurate;Which can be used for quality control of corni fructus soft nanocapsule.

关 键 词：山茱萸纳米软胶囊 熊果酸 马钱苷 高效液相色谱法 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]