放射性食管炎中医研究进展  

Advances in Traditional Chinese Medicine for Radiation Esophagitis

作　　者：柏茂树[1,2] 黄杰[1,2] 沈红梅 周映伽[1,2] 朱德志 王轶珊[1,2] 

机构地区：[1]昆明医学院第三附属医院中西医结合科 [2]云南省肿瘤研究所中西医结合肿瘤临床研究中心,昆明650118

出　　处：《中国实验方剂学杂志》2011年第20期293-296,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：云南省教育厅科学研究基金项目(2010Y186);云南省自然科学基金面上项目(2009CD182)

摘　　要：目的:通过文献复习总结放射性食管炎中医病因病机、治疗及实验研究的新进展,探讨目前放射性食管炎中医研究中的问题及未来发展趋势。方法:应用中国知识资源总库CNKI系列数据库和万方数据库等检索系统,检索出2006年以后相关文献,对其符合分析的共16篇文献进行汇总、分析、综述。结果:在临床实践中,采用辩证论治、专病专方、中药注射液、中西医结合、穴位贴敷等治法,能提高放疗完成率,改善临床症状,提高病人生活质量等;实验研究中发现中药能抑制其COX-2、MMPs等mRNA和IL-8、TGF-β1等蛋白的表达,从而减轻辐射所引起的食管损伤的病理改变。结论:中医药防治本病,可使其症状减轻甚至消失,从而使患者得以完成放疗疗程,具有良好的应用前景。但是,目前治疗方法和疗效标准不统一,尚需建立统一疗效标准,做进一步研究。Objective： To summarize the advances on etiology,pathogenesis,treatment and experimental study applying traditional Chinese medicine on radiation esophagitis.And to explore the current problems and future trends about traditional Chinese medicine on radiation esophagitis study.Method： A computer-based onling search of CNKI and Wanfang databases was undertaken for the relevant literature published after 01-2006.The literature of core journals with Chinese languages was choosed as its main references.A total of 16 literatures were selected.Result： In clinical practice,the use of dialectical theory of governance,specific prescription for certain illness,injection of traditional Chinese medicine,integrated traditional chinese and western medicine,acupoint application and other therapies,can improve radiotherapy completion rates,clinical symptoms,patients＇ quality of life and so on.Experimental study found that Chinese herbs can inhibit the expression of mRNA such as COX-2,MMPs and IL-8,TGF-β1 and other proteins,then reduce radiation-induced pathological changes of esophageal injury.Conclusion： Chinese medicine prevention of the disease.Its symptoms can be reduced or even disappeared,allowing patients to complete radiation treatment,with a good prospect.However,the efficacy of current treatment methods and standards are not unified,so it still need to establish uniform treatment standards.It should be explored about radiation esophagitis on traditional Chinese medicine.

关 键 词：放射性食管炎 病因病机 中医药 研究进展 

分 类 号：R287.6[医药卫生—中药学]