英脱利匹特对布比卡因、罗哌卡因,丁卡因心脏抑制家兔模型救治情况比较  

Effects of Intralipid on treatment of a rabbit model with cardiac depression induced by bupivacaine,ropivacaine and tetracaine

作　　者：李晓霞[1] 郎中兵 陈楠[1] 徐昆[1] 

机构地区：[1]重庆医科大学附属第二医院麻醉科,重庆400010 [2]重庆市武警总队医院麻醉科,重庆400061

出　　处：《激光杂志》2011年第5期80-81,共2页Laser Journal

基　　金：重庆市教委资助项目;编号KJ090314

摘　　要：目的:探讨英脱利匹特分别对布比卡因、罗哌卡因、丁卡因心脏抑制家兔模型救治情况。方法:21只家兔随机分为BF组(布比卡因与英脱利匹特组),RF组(罗哌卡因与英脱利匹特组),DF组(丁卡因与英脱利匹特组)。局麻药心脏抑制的中毒模型造模成功后,各组静脉注射英脱利匹特负荷量1ml/kg,以0.5 mL/kg/min的速度匀速输入10 min。家兔平均动脉压和心率恢复至基础值80%视为治疗成功。分别监测并记录各组家兔基础心率和基础平均动脉压、引起中毒的局麻药用量、中毒时间、治疗成功时间以及治疗成功率。结果:三组家兔的基础血压、基础平均动脉压无差异。引起中毒的局麻药剂量,RF组大于BF组与DF组(P<0.05),BF组与DF组间未见明显差异。中毒时间RF组大于BF组与DF组。BF组的治疗成功时间显著大于RF组,与DF组未见明显差异。RF组的治疗成功率高于BF组与DF组。结论:罗哌卡因的心脏毒性低于布比卡因与丁卡因,布比卡因与丁卡因的心脏毒性相当。英脱利匹特对三种局麻药引起的心脏抑制均有拮抗作用。Objective：To investigate the effects of Intralipid on treatment of a rabbit model with cardiac depression induced by bupivacaine , ropivacaine and tetracaine. Methods ： New Zealand White rabbits （ n = 21 ） were randomly divided into three groups which are group BF （ n = 7, treated with bupivacaine plus Intralipid）, group RF（n = 7, treated with ropivacaine plus Intralipid ） and group DF（ n = 7, treated with tetracaine plus Intralipid）. Local anesthetics were injected via rabbit＇s auricular vein, and MAP decreased to 60% of the basic value were served as evidence of successful establishment of cardiac depression models. Then, an IV bolus of Intralipid （1 ml/kg） was given in each group, followed by continuous infusion（0.5ml/kg/min） for 10 minutes. The treatment was suecess when MAP increased to 80% of the basic value. And respectively recorded the basic HR and MAP, the doses of each local anesthetics which induced cardiac depression, the time of poisoning, the time of successful treatment and the treatment success rate. Results：There was no significant difference in basic HR and MAP among the three groups. The doses of each local anesthetics which induced cardiac depression was significantly high in group RF as compared with those in group BF and group DF. The time of poisoning was significantly long in group RF as compared with those in group BF and group DF. The time of succesful treatment in group BF was significantly long as compared with those in group RF. The treatment success rate was high in group RF as compared with group BF and group DF. Conclusions：Ropivacaine had less cardiac toxicity than bupivacaine and tetracaine. Bupivacaine and tetracainthe almost had corresponding cardiac toxicity. Intralipid has rivalry effect on cardiac toxicity induced by bupivacaine, ropivacaine and tetracaine.

关 键 词：英脱利匹特 布比卡因 罗哌卡因 丁卡因 心脏抑制 

分 类 号：R477[医药卫生—护理学]