油樟叶挥发油对兔的急性皮肤刺激、眼睛刺激和皮肤光毒性的研究  

Research on Dermal Toxicity and Eye Toxicity of the Volatile Oil from the Leaf of Cinnamomum Longepaniculatum

作　　者：张笑乐[1] 向楠[1] 殷中琼[1,2] 尚永祥[3] 余孟骁[4] 游飞[1] 付强[1] 夏春丽[1] 申义君[1] 

机构地区：[1]四川农业大学动物医学院,四川雅安625014 [2]四川农业大学动物疫病与人类健康四川省重点实验室,四川雅安625014 [3]四川农业大学生命科学与理学院,四川雅安625014 [4]四川农业大学风景园林学院,成都611130

出　　处：《中国农学通报》2011年第23期36-39,共4页Chinese Agricultural Science Bulletin

基　　金：教育部<长江学者和创新团队发展计划>创新团队项目"新中兽药的研发"(IRTO848)

摘　　要：试验通过对兔的一次给药和多次给药皮肤刺激试验、一次给药和多次给药的眼睛刺激试验和皮肤光毒性试验,观察皮肤反应和眼睛反应,评价油樟叶挥发油的皮肤刺激性、眼睛刺激性和光毒性。结果表明一次和多次用药高、中剂量油樟叶挥发油对破损皮肤有可逆性刺激,低剂量无刺激;三个剂量对完整皮肤均无刺激。一次用药对眼睛有轻微可逆刺激,多次用药对个别个体造成不可逆损伤。油樟叶挥发油无光毒性。说明中剂量以下油樟叶挥发油皮肤用药较为安全,眼睛用药要慎重。Evaluate the security of the volatile oil from the leaf of Cinnamomum Longepaniculatum by carrying on the skin irritation,the eye irritation test and the phototoxicity test and observing the response.The result shows that the high and the middle concentrations had slight and reversible irritation to the damaged skin,but the low concentration didn ＇ t.Those three all had no irritation to the intact skin.When the volatile oil from the leaf of Cinnamomum Longepaniculatum was given to the eyes once,it had slight and reversible irritation,yet it became irreversible when given several times to a few rabbits.The volatile oil from the leaf of Cinnamomum Longepaniculatum had no phototoxicity.As a whole,it ＇ s safe to apply the volatile oil from the leaf of Cinnamomum Longepaniculatum to the skin,while the application to the eyes must be careful.

关 键 词：油樟叶 挥发油 皮肤刺激 眼刺激 光毒性 

分 类 号：R965.3[医药卫生—药理学]