磁小体研究进展  

Progress in the Study of Magnetosome

作　　者：高宗良[1] 谷元兴[1] 赵峰[1] 刘永生[1] 

机构地区：[1]中国农业科学院兰州兽医研究所/家畜疫病病原生物学国家重点实验室农业部畜禽病毒学重点开放实验室/农业部兽医公共卫生重点开放实验室,兰州730046

出　　处：《中国农学通报》2011年第24期8-12,共5页Chinese Agricultural Science Bulletin

基　　金：国际科技合作项目"猪蓝耳病发病机制与诊断新技术合作研究"(2010DFA32640)

摘　　要：趋磁细菌(magnetotactic bacteria,MTB)能够在细胞内合成由生物膜包裹的纳米级磁铁矿粒子——磁小体(magetosome)。磁小体的合成过程,尤其是铁离子的反应途径及吸收转运受到严格的生物调控。磁小体完美的晶体结构使其在医学成像、磁介导热疗、药物输送等众多领域都有良好的应用价值。主要综述了磁小体矿化过程中铁的反应途径和吸收转运系统,以及磁小体在各方面的应用,并对未来的研究方向做了展望。Magnetotactic bacteria（MTB） are capable of forming nano-magnetite particles enveloped by a biological membrance in vivo,which are called magnetosome.The biosynthesis of magnetosome especially mechanisms of iron uptake and transport process with very strict controls.The crystallographic perfection of magnotosome has attracted interest in its use as magnetic nanoparticles in medical imaging,magnetic-mediated hyperthermia,drug delivery and other fields.This paper reviews the magnetosome biomineralization mainly on the pathway of iron reaction and iron uptake transport system,describes the magnetosome in the application of the above and put forward the future directions.

关 键 词：磁小体 铁反应途径 吸收转运 应用 

分 类 号：Q939.9[生物学—微生物学]