高等真核生物基因组isochore边界确定中的对称性  

Measures of Symmetry in the Identifying Isochore Boundaries of Eukaryotic Genomes

作　　者：崔家峰[1] 

机构地区：[1]天津科技大学理学院,天津300457

出　　处：《天津科技大学学报》2011年第5期72-75,共4页Journal of Tianjin University of Science & Technology

摘　　要：高等真核生物基因组的isochore结构与许多重要的生物学特征相关,而对其边界的确定则是isochore结构分析的重点,同时也是难点.针对基于Z曲线的累积GC轮廓图法、基于Shannon熵的递归分段算法以及基于二次散度的分段算法三种典型的应用,分析出其分段依据本质上是对于基因组序列求取碱基对换对称性的对称中心.基于此结果,在寻找isochore结构分析度量时,只要度量函数满足一定对换对称性要求,即可达到殊途同归的目的.Many higher eukaryotic genomes are composed of large sequence segments with fairly homogeneous GC content, namely isochores, which have been linked to many important biological functions. It is not only important but also difficult to determine the isohore boundaries. Three methods, GC-Profile algorithm based on Z curve, recursive segmentation algorithm based on Shannon entropy and on quadratic divergence, are analyzed and conclusion is drawn that the common feature of three algorithms is to find the symmetry center of the genome sequence. Based on this result, the same purposes can be achieved as long as the measure functions for the analysis of the isochore structures meet some exchange symmetry requirements.

关 键 词：真核生物 基因组 ISOCHORE Z曲线 Shannon熵 

分 类 号：Q811.4[生物学—生物工程]