痛风的诊断与治疗  

Diagnosis and treatment of gout

作　　者：李强[1] 于萍[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科,150086

出　　处：《国际内分泌代谢杂志》2011年第5期289-291,共3页International Journal of Endocrinology and Metabolism

摘　　要：正常情况下，人体每天尿酸的产生和排泄基本上保持动态平衡，凡是影响血尿酸生成和（或）排泄的因素均可以导致血尿酸水平增加。约有5％～12％的高尿酸血症患者最终会发展成为痛风。痛风的诊断标准有罗马标准、纽约标准、美国风湿病学会（ACR）标准、欧洲抗风湿病联盟（EU—LAR）关于痛风的诊断建议。痛风急性发作期的治疗包括卧床休息、多喝水、进食低嘌呤饮食、首选并早用非甾体抗炎药、必要时可使用秋水仙碱和糖皮质激素，EULAR对痛风治疗提出12项建议。英国风湿病协会（BSR）指南、日本指南、中国指南分别推荐在痛风间歇期和慢性期使用降尿酸药物的时机。痛风的治疗应强调急性期的治疗，同时应关注缓解期的降尿酸治疗，尤其是分层的降尿酸治疗。The production and excretion of uric acid per day in the body maintain dynamic balance basically under normal circumstances, and any factor, affects formation and （or） excretion of uric acid, can lead to increased serum uric acid level. There are about 5% -12% of patients with hyperuricemia（HUA） will eventually develop into gout. The diagnosis standards of Roman, New York, American College of Rhenmatology （ACR）, and the recommendations on the diagnosis of the European Union League Against Rheumatism （EULAR） are introduced. The treatment of acute attack of gout include bed rest, drinking plenty of water, and eating low-purine diet. And non-steroidal anti-inflammatory drugs are preferred and should be used early. Colchicine and eorticosteroids can be used when necessary. Furthermore, 12 pieces of advice about gout are advised by EULAR. Appropriate time of lowering uric acid drugs during intermittent and chronic phase are analysised, based on British Society for Rheumatology Guidelines （BSR） , Chinese guides, and Japan guides. Recent guidelines emphasize the treatment of acute phase, and begin to focus on uric acid-lowering therapy in remission, especially stratification treatment of lowering uric acid.

关 键 词：痛风 诊断 治疗 

分 类 号：R589.7[医药卫生—内分泌]