线粒体功能在骨骼肌胰岛素抵抗中的作用  

The role of mitochondrial function in skeletal muscle insulin resistance

作　　者：张克莹[1] 都健[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110001

出　　处：《国际内分泌代谢杂志》2011年第5期317-320,共4页International Journal of Endocrinology and Metabolism

基　　金：辽宁省科学技术计划项目（2009225029）;辽宁省教育厅科学技术研究项目（L2010597）

摘　　要：线粒体是提供细胞进行各种生命活动所需能量的细胞器，越来越多的证据表明，线粒体功能与骨骼肌胰岛素抵抗状态密切相关，这种机制可能因为线粒体功能损伤引发脂肪酸β-氧化功能障碍，最终影响胰岛素受体后信号转导通路而致胰岛素抵抗的发生；也可因为线粒体融合蛋白或基因调控受损造成线粒体动力学异常或膜电位下降，造成胰岛素抵抗。目前对于线粒体功能障碍的研究，尤其是氧化应激机制的研究，可为治疗2型糖尿病提供新的思路。Mitochondria are the organclles which can provide energy to can＇y out various life activi- ties. More and more evidences have shown that mitochondrial dysfunction is closely related to skeletal muscle insulin resistance. The mechanism may be the dysfunction of fatty acid beta oxidation, caused by the damage of mitochondria thus ＇affecting insulin receptor signaling pathways, and finally resulting in the occurrence of insulin resistance. In addition, dysregulation of mitochondria fusion protein and gene expression can cause abnormal mitochondria dynamics or downregulation of membrane potential, finally leads to insulin resistance. The current research on mitochondrial dysfunction, especially oxidative stress will provide new ideas for the treatment of type 2 diabetes.

关 键 词：线粒体 骨骼肌 胰岛素抵抗 2型糖尿病 

分 类 号：R587[医药卫生—内分泌]